Ethyl 2-methylacetoacetate

Names

[ CAS No. ]:
609-14-3

[ Name ]:
Ethyl 2-methylacetoacetate

[Synonym ]:
2OVY1&V1
Butanoic acid, 2-methyl-3-oxo-, ethyl ester
Ethyl 2-methyl-3-oxobutanoate
MFCD00009164
Ethyl 2-methylacetoacetate
EINECS 210-179-9

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
185.8±8.0 °C at 760 mmHg

[ Melting Point ]:
-45 °C

[ Molecular Formula ]:
C₇H₁₂O₃

[ Molecular Weight ]:
144.168

[ Flash Point ]:
68.9±18.5 °C

[ Exact Mass ]:
144.078644

[ PSA ]:
43.37000

[ LogP ]:
1.06

[ Vapour Pressure ]:
0.7±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.414

[ Storage condition ]:
-20°C Freezer

[ Water Solubility ]:
IMMISCIBLE

MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
1993

[ WGK Germany ]:
3

[ HS Code ]:
2918300090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Ethyl acetoacetate
methyl iodide
Methyl bromide
1-(3,5-Dimethyl-pyrazol-1-yl)-ethanone
Ethyl (2S)-2-bromopropanoate
Bromo(isopropyl)magnesium
2-OXAZOLIDINONE, 3-ACETYL-
ethyl acetate
n-Ethyl propanoate

DownStream

ethyl 2-methyl-3-oxooct-6-enoate
6-ethyl-7-methoxy-3,4-dimethylchromen-2-one
prop-2-enyl 2-methyl-3-oxobutanoate
7-hydroxy-3,4,5-trimethylchromen-2-one
ethyl 2-(bromomethyl)-2-methyl-3-oxobutanoate
5-hydroxy-3,4,7-trimethylchromen-2-one
methyl 3-hydroxy-4,5-dimethylthiophene-2-carboxylate
2-Butanone,4-hydroxy-3-methyl-
Mesaconic acid
2-Methyl-3-hydroxybutyric acid

Customs

[ HS Code ]: 2918300090

[ Summary ]:
2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Asymmetric reduction of ethyl 2-methyl 3-oxobutanoate by Chlorella.

Biosci. Biotechnol. Biochem. 63(3) , 598-601, (1999)

Chlorella pyrenoidosa Chick reduced ethyl 2-methyl 3-oxobutanoate to the corresponding alcohols with the diastereomer (anti/syn) ratio of 53/47. The enantiomer excesses of anti-(2S, 3S)- and syn-(2S, ...

Asymmetric reduction of ethyl 2-methyl e-oxobutanoate by fungi.

Biosci. Biotechnol. Biochem. 64(1) , 194-7, (2000)

Seven fungi, which are found to reduce ethyl 3-oxobutanoate in high yields, were tested for their reducing ability for ethyl 2-methyl 3-oxobutanoate. We obtained some interesting findings. In particul...