Phenylephrine hydrochloride

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Names

[ CAS No. ]:
61-76-7

[ Name ]:
Phenylephrine hydrochloride

[Synonym ]:
consdrin
(R)-3-Hydroxy-a-[(methylamino)methyl]benzenemethanol Hydrochloride
(R)-(-)-Phenylephrine (hydrochloride)
almefrin
synasal
phenylephrine HCl
3-[(1R)-1-Hydroxy-2-(methylamino)ethyl]phenol hydrochloride (1:1)
3-[(1R)-1-hydroxy-2-(méthylamino)éthyl]phénol chlorhydrate
l-1-(m-Hydroxyphenyl)-2-methylaminoethanol Hydrochloride
emagrin
fenilfar
AK-Dilate
Benzenemethanol, 3-hydroxy-α-[(methylamino)methyl]-, (αR)-, hydrochloride (1:1)
benzenemethanol, 3-hydroxy-α-[(methylamino)methyl]-, (αR)-, hydrochloride
rhinall
l-a-Hydroxy-b-methylamino-3-hydroxy-1-ethylbenzene Hydrochloride
AK-Nefrin
m-Sympatol
Metaoxedrin
Pyracort D
Phenylephrine hydrochloride
efricel
Mezaton
lexatol
uri
fenox
EINECS 200-517-3
MFCD00012605
1-m-Hydroxy-a-[(methylamino)methyl]benzyl Alcohol Hydrochloride
Isophrin
3-[(1R)-1-Hydroxy-2-(methylamino)ethyl]benzololhydrochlorid

Chemical & Physical Properties

[ Boiling Point ]:
341.1ºC at 760 mmHg

[ Melting Point ]:
143-145 °C(lit.)

[ Molecular Formula ]:
C₉H₁₄ClNO₂

[ Molecular Weight ]:
203.666

[ Flash Point ]:
163.4ºC

[ Exact Mass ]:
203.071304

[ PSA ]:
52.49000

[ LogP ]:
1.83790

[ Index of Refraction ]:
-45.5 ° (C=1, H2O)

[ Water Solubility ]:
>=10 g/100 mL at 21 ºC

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DO7525000

CHEMICAL NAME :: Benzyl alcohol, m-hydroxy-alpha-((methylamino)methyl)-, hydrochloride, (-)-

CAS REGISTRY NUMBER :: 61-76-7

LAST UPDATED :: 199706

DATA ITEMS CITED :: 23

MOLECULAR FORMULA :: C9-H13-N-O2.Cl-H

MOLECULAR WEIGHT :: 203.69

WISWESSER LINE NOTATION :: QR CYQ1M1 &GH -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Ocular

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Brain and Coverings - changes in circulation (hemorrhage, thrombosis, etc.) Behavioral - muscle weakness

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 17 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 27 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 440 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 89 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 22 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1120 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 16 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 22 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 7200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 84 gm/kg/12W-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - miosis (pupillary constriction) Cardiac - changes in heart weight Endocrine - changes in adrenal weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 202 gm/kg/12W-I

TOXIC EFFECTS :: Cardiac - changes in heart weight Endocrine - changes in adrenal weight Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 15 mg/kg

SEX/DURATION :: female 22-31 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - parturition Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 1500 mg/L

REFERENCE :: NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-322,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0845 No. of Facilities: 169 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 4376 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0845 No. of Facilities: 360 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 14244 (estimated) No. of Female Employees: 10911 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
3249

[ WGK Germany ]:
3

[ RTECS ]:
DO7525000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2937229000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Phenylephrone Hydrochloride
(R)-(-)-Phenylephrine
(S)-2-(benzyl(methyl)amino)-1-(3-(benzyloxy)phenyl)ethanol hydrochloride
methylamine
(R)-3-(1-hydroxy-2-iodoethyl)phenol
rac Benzyl Phenylephrine
1-(3-Hydroxyphenyl)-2-[methyl(phenylmethyl)amino]-ethanone hydrochloride
3-Hydroxybenzaldehyde
3'-benzyloxy-2-(N-benzyl-N-methyl)aminoacetophenone hydrochloride
3-[tert-butyl(dimethyl)silyl]oxybenzaldehyde

DownStream

(R)-5-(3-Hydroxyphenyl)-3-methyl-2-oxazolidinone
Phenylephrine hydrochloride

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Receptor mediated disruption of retinal pigment epithelium function in acute glycated-albumin exposure.

Exp. Eye Res. 137 , 50-6, (2015)

Diabetic macular edema (DME) is a major cause of visual impairment. Although DME is generally believed to be a microvascular disease, dysfunction of the retinal pigment epithelium (RPE) can also contr...

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

Formulation and stability study of a pediatric 2% phenylephrine hydrochloride eye drop solution.

Ann. Pharm. Fr. 73(1) , 31-6, (2015)

We present formulation and stability evaluation of a 2% (w/v) phenylephrine hydrochloride biocompatible eye drop solution, routinely prepared in hospital pharmacy under aseptic conditions, for retinal...

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1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 3-cyclopropyl-1H-pyrazole-4-carboxylate
1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylate
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1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 2-(4-methylpiperazin-1-yl)acetate
1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 2-(piperidin-1-yl)propanoate
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