2,4-Dihydroxy-5-nitropyrimidine

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Names

[ CAS No. ]:
611-08-5

[ Name ]:
2,4-Dihydroxy-5-nitropyrimidine

[Synonym ]:
2,4(1H,3H)-Pyrimidinedione, 5-nitro-
5-nitropyrimidine-2,4(1H,3H)-dione
5-NITRO-2,4-PYRIMIDINEDIOL
5-Nitro-2,4(1H,3H)-pyrimidinedione
5-nitro-1H-pyrimidine-2,4-dione
5-nitropyrimidine-2,4-diol
MFCD00006021
2,4-Dihydroxy-5-Nitropyrimidine
5-Nitro-1H-pyrimidin-2,4-dion
5-Nitropyrimidin-2,4(1H,3H)-dion
NITROURACIL
Uracil,5-nitro
4(1H)-pyrimidinone, 2-hydroxy-5-nitro-
2-Hydroxy-5-nitropyrimidin-4(1H)-one
5-nitro-uracil
EINECS 210-250-4
5-NITROURACIL extrapure

Chemical & Physical Properties

[ Density]:
1.9±0.1 g/cm3

[ Boiling Point ]:
453.3±48.0 °C at 760 mmHg

[ Melting Point ]:
>300 °C(lit.)

[ Molecular Formula ]:
C4H3N3O4

[ Molecular Weight ]:
157.084

[ Flash Point ]:
227.9±29.6 °C

[ Exact Mass ]:
157.012360

[ PSA ]:
111.54000

[ LogP ]:
-1.72

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.701

[ Storage condition ]:
-20°C Freezer

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
C: Corrosive;F: Flammable;

[ Risk Phrases ]:
R11

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
UV9104545

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Uracil
  • 6-Methyluracil
  • 4 (1H)-Pyrimidinone, 2-(ethylthio)-
  • 2-Thiouracil
  • 2,4-Dichloro-5-nitropyrimidine
  • Nitro-orotic acid
  • 5-nitro-2'-deoxyuridine
  • 4(1H)-Pyrimidinone,2-amino-5-nitro-
  • Sulfuric acid

DownStream

  • 2-(formylcarbamoylamino)-2-oxoacetic acid
  • 2,4-Dichloro-5-nitropyrimidine
  • 2,4(1H,3H)-Pyrimidinedione,1,3-dimethyl-5-nitro-
  • 1-methyl-5-nitro-2,4(1H,3H)pyrimidinedione
  • 2,4(1H,3H)-Pyrimidinedione,3-methyl-5-nitro-
  • 1(2H)-Pyrimidinepropanoicacid, 3,4-dihydro-5-nitro-2,4-dioxo-, ethyl ester
  • 1(2H)-Pyrimidinebutanoicacid, 3,4-dihydro-5-nitro-2,4-dioxo-, ethyl ester
  • 5-Hydroxyuracil
  • 5-Aminouracil
  • 1-(2-hydroxyethoxymethyl)-5-nitropyrimidine-2,4-dione

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Phenobarbital induction and chemical synergism demonstrate the role of UDP-glucuronosyltransferases in detoxification of naphthalophos by Haemonchus contortus larvae.

Antimicrob. Agents Chemother. 58(12) , 7475-83, (2014)

We used an enzyme induction approach to study the role of detoxification enzymes in the interaction of the anthelmintic compound naphthalophos with Haemonchus contortus larvae. Larvae were treated wit...

Inhibition of UDP-glucuronyltransferase activity in rat liver microsomes by pyrimidine derivatives.

Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. 112(3) , 321-5, (1995)

Thirty-one differently substituted pyrimidine bases were tested for their inhibitory effect on the glucuronidation of 4-nitrophenol and phenolphthalein by rat liver microsomes. 5-Nitrouracil (compound...

Thymidine phosphorylase inhibitors with a homophthalimide skeleton.

Biol. Pharm. Bull. 24(7) , 860-2, (2001)

Several N-phenylhomophthalimide derivatives were prepared and their inhibitory activity on thymidine phosphorylase/ platelet-derived endothelial cell growth factor (TP/PD-ECGF) was assessed. Among the...


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Related Compounds

  • 6-isopropyl-2,4-dihydroxy-5-nitropyrimidine
  • (2,4-dihydroxy-5-methylphenyl)-(3-hydroxyphenyl)methanone
  • 2,4-dihydroxy-5-[(E)-3-phenylprop-2-enoyl]benzoic acid
  • 2,4-dihydroxy-5,6,7,8,8a,10-hexahydro-4bH-phenanthren-9-one
  • 2,4-dihydroxy-5-carboxylic acid-pyrimidine
  • 2,4-dihydroxy-5-methoxybenzoic acid