8-Methylquinoline

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Names

[ CAS No. ]:
611-32-5

[ Name ]:
8-Methylquinoline

[Synonym ]:
Quinoline,8-methyl
8-methyl quinoline
Quinoline, 8-methyl-
8-Methyl-chinolin
O-Toluquinoline
MFCD00006810
8-Methylquinoline
EINECS 210-264-0
Fasudil Impurity 11

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
247.5±0.0 °C at 760 mmHg

[ Melting Point ]:
-80 °C

[ Molecular Formula ]:
C10H9N

[ Molecular Weight ]:
143.185

[ Flash Point ]:
105.0±0.0 °C

[ Exact Mass ]:
143.073502

[ PSA ]:
12.89000

[ LogP ]:
2.54

[ Vapour Pressure ]:
0.0±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.625

[ Water Solubility ]:
0.1-0.5 g/100 mL at 17 ºC

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VC0562000
CHEMICAL NAME :
Quinoline, 8-methyl-
CAS REGISTRY NUMBER :
611-32-5
BEILSTEIN REFERENCE NO. :
0111340
LAST UPDATED :
199701
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C10-H9-N
MOLECULAR WEIGHT :
143.20

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Unscheduled DNA synthesis
TEST SYSTEM :
Rodent - rat Liver
DOSE/DURATION :
1 mmol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 12,217,1991

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36/37/38;R68

[ Safety Phrases ]:
S26-S36-S45-S36/37/39

[ RIDADR ]:
2810.0

[ WGK Germany ]:
3

[ RTECS ]:
VC0562000

[ Hazard Class ]:
6.1

[ HS Code ]:
2933499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Glycerol
  • o-Toluidine
  • 3-[bis(3-hydroxypropyl)amino]propan-1-ol
  • 2-Nitrotoluene
  • 8-Methyl-1,2,3,4-tetrahydroquinoline
  • 3-Aminopropan-1-ol
  • 1,3-Propanediol
  • 5-Chloro-8-methylquinoline
  • 2-Bromoaniline
  • 8-methyl quinoline borane

DownStream

  • 1,2,3,4-tetrahydroquinolin-8-ylmethanol
  • Quinoline-8-carbaldehyde
  • Methyl 5-bromoquinoline-8-carboxylate
  • 8-Ethylquinoline
  • 5-Chloro-8-methylquinoline
  • 5,7-dichloro-8-methylquinoline
  • Quinoline-8-carboxylic acid
  • 2-acetonicotinic acid
  • 7-Chloro-8-methylquinoline
  • Quinolinic acid

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

A P450 BM-3 mutant hydroxylates alkanes, cycloalkanes, arenes and heteroarenes.

J. Biotechnol. 88(2) , 167-71, (2001)

P450 monooxygenases from microorganisms, similar to those of eukaryotic mitochondria, display a rather narrow substrate specificity. For native P450 BM-3, no other substrates than fatty acids or an in...

The hepatic metabolism of two methylquinolines.

Carcinogenesis 14(5) , 1041-7, (1993)

The hepatic microsomal metabolism of the carcinogenic 8-methylquinoline (8MQ) and its noncarcinogenic isomer, 6-methylquinoline (6MQ), were compared for preparations from control rats and rats pretrea...

Carcinogenicity of quinoline, 4- and 8-methylquinoline and benzoquinolines in newborn mice and rats.

Food Chem. Toxicol. 26(7) , 625-9, (1988)

The relative tumorigenic activity of quinoline, 4-methylquinoline, 8-methylquinoline, and all three isomeric benzoquinolines was evaluated in newborn CD-1 mice and Sprague-Dawley rats. In the newborn-...


More Articles

Related Compounds

  • 8-Methylquinoline
  • 8-methylquinoline oxide
  • 5-iodo-8-methylquinoline
  • 4-AMINO-8-METHYLQUINOLINE
  • bromine,8-methylquinoline
  • 5-Cyano-8-methylquinoline
  • N-(2-chlorophenyl)-2-((6-(3-methoxybenzyl)-5,5-dioxido-6H-benzo[c]pyrimido[4,5-e][1,2]thiazin-2-yl)thio)acetamide
  • methyl 2-(2-((2,4-dimethoxyphenyl)amino)-2-oxoethyl)-4-phenyl-2H-benzo[e][1,2]thiazine-3-carboxylate 1,1-dioxide
  • 2-((3-(2-chlorobenzyl)-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(4-fluorobenzyl)acetamide
  • methyl 2-(2-((2-chlorophenyl)amino)-2-oxoethyl)-4-phenyl-2H-benzo[e][1,2]thiazine-3-carboxylate 1,1-dioxide
  • methyl 2-(2-oxo-2-{[2-(trifluoromethyl)phenyl]amino}ethyl)-4-phenyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide
  • 3-{[Methyl(4-methylphenyl)amino]sulfonyl}-4-phenylthiophene-2-carboxylic acid
  • 2-[(3-ethyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(3-ethylphenyl)acetamide
  • Benzyl (4-(4-(benzo[d][1,3]dioxol-5-yl)-3-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl)cyclohexyl)carbamate
  • Hexanoic acid, 6-[[(4-aminophenyl)sulfonyl]amino]-, hydrochloride (1:1)
  • 1-(3-(4-(4-acetylphenyl)piperazin-1-yl)-3-oxopropyl)-4-ethylthieno[2,3-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one
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