Flumezapine

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Names

[ CAS No. ]:
61325-80-2

[ Name ]:
Flumezapine

[Synonym ]:
Flumezapinum [INN-Latin]
Flumezapine (USAN)
Flumezapinum
10H-Thieno(2,3-b)(1,5)benzodiazepine,7-fluoro-2-methyl-4-(4-methyl-1-piperazinyl)
Flumezapina [INN-Spanish]
7-fluoro-2-methyl-4-(4-methyl-piperazin-1-yl)-10H-benzo[b]thieno[2,3-e][1,4]diazepine
Flumezapina
FLUMEZAPINE
7-Fluoro-2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno(2,3-b)(1,5)benzodiazepine

Chemical & Physical Properties

[ Density]:
1.383g/cm3

[ Boiling Point ]:
479.498ºC at 760 mmHg

[ Molecular Formula ]:
C17H19FN4S

[ Molecular Weight ]:
330.42300

[ Flash Point ]:
243.792ºC

[ Exact Mass ]:
330.13100

[ PSA ]:
59.11000

[ LogP ]:
3.02770

[ Index of Refraction ]:
1.697

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XJ9007100
CHEMICAL NAME :
10H-Thieno(2,3-b)(1,5)benzodiazepine, 7-fluoro-2-methyl-4-(4-methyl-1-piperazinyl)-
CAS REGISTRY NUMBER :
61325-80-2
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C17-H19-F-N4-S
MOLECULAR WEIGHT :
330.46

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 23,878,1980

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • methylpiperazine
  • 7-fluoro-2-methyl-5,10-dihydro-benzo[b]thieno[2,3-e][1,4]diazepin-4-one

DownStream

Related Compounds

  • 3-Cyclopropoxy-5-ethylisonicotinonitrile
  • 5-Chloro-2-(cyclopropylmethoxy)phenol
  • 5-Cyclopropoxy-4-isopropyl-N,N-dimethylnicotinamide
  • 1-Cyclopropoxy-3,5-diisopropoxycyclohexa-1,3-diene
  • 5-Cyclopropoxy-3-isopropyl-2-methylpyridine
  • 2-(Aminomethyl)-4-hydroxybenzaldehyde
  • 2-Hydroxy-3-(methylcarbamoyl)benzoic acid
  • 4-Cyclopropoxy-3-isopropoxy-N,N-dimethylpyridin-2-amine
  • 4-Cyclopropoxy-N-methyl-3-nitrobenzamide
  • N-(5-Tert-butyl-3-cyclopropoxypyridin-2-YL)methanesulfonamide
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