Flumezapine

Modify Date: 2026-07-26 14:24:07

Flumezapine structure	Common Name	Flumezapine
	CAS Number	61325-80-2	Molecular Weight	330.42300
	Density	1.383g/cm3	Boiling Point	479.498ºC at 760 mmHg
	Molecular Formula	C₁₇H₁₉FN₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	243.792ºC

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	7-fluoro-2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[3,2-c][1,5]benzodiazepine
Synonym	More Synonyms

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.383g/cm3
Boiling Point	479.498ºC at 760 mmHg
Molecular Formula	C₁₇H₁₉FN₄S
Molecular Weight	330.42300
Flash Point	243.792ºC
Exact Mass	330.13100
PSA	59.11000
LogP	3.02770
Index of Refraction	1.697

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XJ9007100

CHEMICAL NAME :: 10H-Thieno(2,3-b)(1,5)benzodiazepine, 7-fluoro-2-methyl-4-(4-methyl-1-piperazinyl)-

CAS REGISTRY NUMBER :: 61325-80-2

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C17-H19-F-N4-S

MOLECULAR WEIGHT :: 330.46

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 23,878,1980

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

methylpiperazine

CAS#:109-01-3

7-fluoro-2-meth...

CAS#:61325-55-1

~35%

Flumezapine

CAS#:61325-80-2

Learn More

Literature: Chakrabarti, Jiban K.; Horsman, Linda; Hotten, Terrence M.; Pullar, Ian A.; Tupper, David E. Journal of Medicinal Chemistry, 1980 , vol. 23, # 8 p. 878 - 884

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 2
CAS#:109-01-3 methylpiperazine CAS#:61325-55-1 7-fluoro-2-meth...
DownStream 0

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Tested for physostigmine lethality at a dose of 2.5 mg/kg after oral administration i...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL743061

Name: Compound was assessed for its ability to block a conditioned avoidance response; Dose...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL775310

Name: Displacement of [3H]spiroperidol from Dopamine receptor of rat striatum membrane
Source: ChEMBL
Target: D(2) dopamine receptor
External Id: CHEMBL672127

Name: Tested for physostigmine lethality at a dose of 5 mg/kg after oral administration in ...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL738708

Name: Rotarod response in rat to assess muscular incoordination (following p.o. dosing)
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL775217

Name: Inhibitory activity against muscarinic cholinergic receptors in male olac rat brain, ...
Source: ChEMBL
Target: Muscarinic acetylcholine receptor M2
External Id: CHEMBL744142

Name: Compound administered perorally was evaluated for the conditioned avoidance response ...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL775219

Name: Inhibition of [3H]QNB binding to muscarinic cholinergic receptor from male Olac rat b...
Source: ChEMBL
Target: Muscarinic acetylcholine receptor M2
External Id: CHEMBL744002

Name: compound behavior in rat
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL779450

Name: Displacement of [3H]QNB from Muscarinic acetylcholine receptor of rat brain membrane
Source: ChEMBL
Target: Muscarinic acetylcholine receptor M2
External Id: CHEMBL746568

Total 22, Current Page 1 of 3

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Flumezapinum [INN-Latin]

Flumezapine (USAN)

Flumezapinum

10H-Thieno(2,3-b)(1,5)benzodiazepine,7-fluoro-2-methyl-4-(4-methyl-1-piperazinyl)

Flumezapina [INN-Spanish]

7-fluoro-2-methyl-4-(4-methyl-piperazin-1-yl)-10H-benzo[b]thieno[2,3-e][1,4]diazepine

Flumezapina

FLUMEZAPINE

7-Fluoro-2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno(2,3-b)(1,5)benzodiazepine

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the polar surface area (PSA) of 7-fluoro-2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[3,2-c][1,5]benzodiazepine?

A: Polar surface area (PSA) of 7-fluoro-2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[3,2-c][1,5]benzodiazepine is 59.11000.

Q: What English synonyms does 7-fluoro-2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[3,2-c][1,5]benzodiazepine have?

A: English synonyms of 7-fluoro-2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[3,2-c][1,5]benzodiazepine: Flumezapinum [INN-Latin], Flumezapine (USAN), Flumezapinum, 10H-Thieno(2,3-b)(1,5)benzodiazepine,7-fluoro-2-methyl-4-(4-methyl-1-piperazinyl), Flumezapina [INN-Spanish], 7-fluoro-2-methyl-4-(4-methyl-piperazin-1-yl)-10H-benzo[b]thieno[2,3-e][1,4]diazepine, Flumezapina, FLUMEZAPINE, 7-Fluoro-2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno(2,3-b)(1,5)benzodiazepine.

Q: What is the CAS number of 7-fluoro-2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[3,2-c][1,5]benzodiazepine?

A: CAS number of 7-fluoro-2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[3,2-c][1,5]benzodiazepine is 61325-80-2.

Q: What is the boiling point of 7-fluoro-2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[3,2-c][1,5]benzodiazepine?

A: Boiling point of 7-fluoro-2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[3,2-c][1,5]benzodiazepine is 479.498ºC at 760 mmHg.

Q: What is the LogP of 7-fluoro-2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[3,2-c][1,5]benzodiazepine?

A: LogP of 7-fluoro-2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[3,2-c][1,5]benzodiazepine is 3.02770.

Q: What is the molecular weight of 7-fluoro-2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[3,2-c][1,5]benzodiazepine?

A: Molecular weight of 7-fluoro-2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[3,2-c][1,5]benzodiazepine is 330.42300.

Q: What are the upstream materials of 7-fluoro-2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[3,2-c][1,5]benzodiazepine?

A: Related upstream materials(CAS) of 7-fluoro-2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[3,2-c][1,5]benzodiazepine: 109-01-3;61325-55-1.

Q: What is the molecular formula of 7-fluoro-2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[3,2-c][1,5]benzodiazepine?

A: Molecular formula of 7-fluoro-2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[3,2-c][1,5]benzodiazepine is C17H19FN4S.

Q: What is the English name of 7-fluoro-2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[3,2-c][1,5]benzodiazepine?

A: The English name of 7-fluoro-2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[3,2-c][1,5]benzodiazepine is 7-fluoro-2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[3,2-c][1,5]benzodiazepine.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Dayang Chem (Hangzhou) Co., Ltd.

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Flumezapine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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