3-Amino-1,2-propanediol

Names

[ CAS No. ]:
616-30-8

[ Name ]:
3-Amino-1,2-propanediol

[Synonym ]:
1,2-Propanediol, 3-amino-
3-Amino-1,2-propanediol
EINECS 210-475-8
MFCD00008140
3-Amino-1,2-proopanediol
UNII:RH369P864X
3-Aminopropan-1,2-diol
3-aminopropane-1,2-diol

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
266.7±20.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃H₉NO₂

[ Molecular Weight ]:
91.109

[ Flash Point ]:
115.1±21.8 °C

[ Exact Mass ]:
91.063332

[ PSA ]:
66.48000

[ LogP ]:
-1.98

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.496

[ Water Solubility ]:
soluble

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TY2800000

CHEMICAL NAME :: 1,2-Propanediol, 3-amino-

CAS REGISTRY NUMBER :: 616-30-8

BEILSTEIN REFERENCE NO. :: 1719121

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C3-H9-N-O2

MOLECULAR WEIGHT :: 91.13

WISWESSER LINE NOTATION :: Z1YQ1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583) Volume(issue)/page/year: -,1,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2460 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583) Volume(issue)/page/year: -,1,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 246 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583) Volume(issue)/page/year: -,1,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 198 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583) Volume(issue)/page/year: -,1,1961

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C:Corrosive

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 2735 8/PG 2

[ WGK Germany ]:
2

[ RTECS ]:
TY2800000

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2922199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

3-Chloro-1,2-propanediol
DL-Glyceric aldehyde
Glycidol
N-(2-FURYLMETHYL)-3-METHOXYPROPAN-1-AMINE
N-(2,3-dibromo-propyl)-acetamide
Ammonia
Water
1-Amino-3-chloropropan-2-ol hydrochloride

DownStream

n-(benzloxycarbonyl)-3-amino-1 2-
3-(tetradecylamino)propane-1,2-diol
3-[2-(2-methoxyphenoxy)ethylamino]propane-1,2-diol
Isoserine
Iohexol Intermediate
Glycerol
2-Methyl-2-propanyl (2-oxoethyl)carbamate
N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide
5-Amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide
(S)-3-Amino-1,2-propanediol

Customs

[ HS Code ]: 2922199090

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Synthesis and properties of DNA-PNA chimeric oligomers.

Nucleic Acids Res. 24(17) , 3357-63, (1996)

Adenine, thymine and cytosine PNA monomers have been prepared using 3-amino-1,2-propanediol as a starting material. The benzoyl group was used to protect the exocyclic amines of the heterocyclic bases...

Competitive inhibition of lipolytic enzymes. II. Preparation of 'monoacylamino' phospholipids.

Biochim. Biophys. Acta 1043(1) , 67-74, (1990)

This paper describes the synthesis of a number of phosphatidylcholines and phosphatidylglycols, in which one fatty acyl ester group is replaced by an acylamino function. The phospholipids, both of the...

Three new derivatives of 3-amino-1,2-propanediol; their spectral properties and biological evaluation.

Acta Pol. Pharm. 58(4) , 249-56, (2001)

Three new derivatives of 3-amino-1,2-propanediol have been synthesized. Full assignments of signals in their 1H- and 13C-NMR spectra are given. The influence of these compounds on the cardiovascular s...

3-Amino-1,2-propanediol
3-Amino-1,2-propanediol
3-Amino-1,2-propanediol
(S)-3-Amino-1,2-propanediol
(RS)-3-amino-1,2-propanediol
N-Fmoc-3-amino-1,2-propanediol
4-ethoxy-N-methyl-N-(3-methyl-1,1-dioxo-1lambda6-thiolan-3-yl)benzene-1-sulfonamide
CID 16265712
1-ethyl-5-(4-methylphenyl)-5,9-dihydrofuro[3',4':5,6]pyrido[2,3-d]pyrimidine-2,4,6(1H,3H,8H)-trione
2,4-Difluorophenyl 4-methylbenzene-1-sulfonate
8-(2,3-Dimethoxyphenyl)-11-methyl-13-propyl-5-oxa-2,11,13-triazatricyclo[7.4.0.0^{3,7}]trideca-1(9),3(7)-diene-6,10,12-trione
4-phenyl-6-((tetrahydrofuran-2-yl)methyl)-3,4,6,7-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-2,5-dione
2-Acetamido-3,5-dimethylbenzoic acid
Thieno[3,2-b]furan
2-(Furan-2-yl)-2-methylpropanoic acid
8-(3-Methylphenyl)-13-propyl-5-oxa-2,11,13-triazatricyclo[7.4.0.0^{3,7}]trideca-1(9),3(7)-diene-6,10,12-trione

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