Fluvoxamine maleat

Suppliers

Names

[ Name ]:
Fluvoxamine maleat

[Synonym ]:
(E)-5-methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone 2-aminoethyloxime maleate
MFCD00269809
(2Z)-But-2-endisäure--(1E)-5-methoxy-1-[4-(trifluormethyl)phenyl]pentan-1-onO-(2-aminoethyl)oxim(1:1)
EINECS 228-994-3
2-[({(1E)-5-Methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene}amino)oxy]ethanamine (2Z)-2-butenedioate
DU 23000 {Maleate}
faverin50
Fluvoxamine Maleat
Fluvoxamine (maleate)
SME 3110 {Maleate}
(E)-fluvoxamine maleate
MK 264 {Maleate}
2-[({(1E)-5-Methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene}amino)oxy]ethanamine (2Z)-but-2-enedioate (1:1)
Fluvoxamine maleate
MK-264
2-{[(E)-{5-Methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene}amino]oxy}ethanamine (2Z)-2-butenedioate (1:1)
2-{[(E)-{5-Methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene}amino]oxy}ethanamine (2Z)-but-2-enedioate (1:1)
(E)-5-methoxy-1-[4-(trifluoromethyl)phenyl]pentan-1-one O-2-aminoethyl oxime (Z)-but-2-enedoic acid salt
1-Pentanone, 5-methoxy-1-[4-(trifluoromethyl)phenyl]-, O-(2-aminoethyl)oxime, (1E)-, (2Z)-2-butenedioate (1:1)
Faverin
Floxyfral
2-[({(1E)-5-Methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene}amino)oxy]ethanamine (2Z)-2-butenedioate (1:1)
Maveral
Dumirox
(E)-5-methoxy-1-[4-(trifluoromethyl)phenyl]pentan-1-one O-2-aminoethyl oxime maleate
acide (2Z)-but-2-ènedioïque - 2-[({(1E)-5-méthoxy-1-[4-(trifluorométhyl)phényl]pentylidène}amino)oxy]éthanamine (1:1)
Luvox
Fevarin
2-[({(1E)-5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene}amino)oxy]ethanamine (2Z)-but-2-enedioate

Chemical & Physical Properties

[ Boiling Point ]:
370.6ºC at 760 mmHg

[ Melting Point ]:
120-121.5ºC

[ Molecular Formula ]:
C₁₉H₂₅F₃N₂O₆

[ Molecular Weight ]:
434.407

[ Flash Point ]:
177.9ºC

[ Exact Mass ]:
434.166473

[ PSA ]:
131.44000

[ LogP ]:
3.61360

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
H2O: soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SA9230000

CAS REGISTRY NUMBER :: 61718-82-9

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C15-H21-F3-N2-O2.C4-H4-O4

MOLECULAR WEIGHT :: 434.46

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 28,4149,1994 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 29120 mg/kg/13W-I

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from stomach Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 28,4149,1994

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 6825 mg/kg/13W-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in platelet count

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 28,4169,1994

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
SA9230000

[ HS Code ]:
2928000090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

1-Pentanone-5-methoxy-1-[4-(trifluoromethyl)phenyl]-oxime
2-Chloroethanamine hydrochloride
Maleic acid

DownStream

Customs

[ HS Code ]: 2928000090

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

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