5-Hydroxyisophthalic acid

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Names

[ CAS No. ]:
618-83-7

[ Name ]:
5-Hydroxyisophthalic acid

[Synonym ]:
1,3-Benzenedicarboxylic acid, 5-hydroxy-
5-hydroxybenzene-1,3-dicarboxylic acid
EINECS 210-565-7
MFCD00002515
5-hydroxy-isophthalic acid
5-Hydroxyisophthalic acid

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
516.9±45.0 °C at 760 mmHg

[ Melting Point ]:
298-302 °C(lit.)

[ Molecular Formula ]:
C8H6O5

[ Molecular Weight ]:
182.130

[ Flash Point ]:
280.5±25.2 °C

[ Exact Mass ]:
182.021530

[ PSA ]:
94.83000

[ LogP ]:
1.60

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.666

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CZ4280000
CHEMICAL NAME :
1,3-Benzenedicarboxylic acid, 5-hydroxy-
CAS REGISTRY NUMBER :
618-83-7
BEILSTEIN REFERENCE NO. :
2693561
LAST UPDATED :
199701
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C8-H6-O5

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 27(2),52,1983

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
CZ4280000

[ HS Code ]:
29182990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Dimethyl 5-hydroxyisophthalate
  • Isophthalic acid
  • 6-methoxy-3-oxo-cyclohepta-1,4,6-trienecarboxylic acid
  • 6-bromo-3-methoxy-5-oxo-cyclohepta-1,3,6-trienecarboxylic acid
  • 5-Aminoisophthalic acid
  • 3-Chloro-5-methylbenzoic acid
  • stipitatic acid
  • Chrysophanic acid
  • 5-Sulfoisophthalic acid
  • rufigallol

DownStream

  • 3,5-Bis(trifluoromethyl)anisole
  • 3,5-Bis(trifluoromethyl)phenol
  • 1,3-Benzenedicarboxaldehyde, 5-hydroxy- (9CI)
  • 5-Methoxyisophthalic acid
  • Methyl 5-methoxy-isophthalate
  • 2-Methoxy-4,6-bis(trifluoromethyl)benzoic acid
  • methyl 3-hydroxy-5-(hydroxymethyl)benzoate
  • BENZOYLOXY-3,5-BENZENEDICARBOXYLICACID
  • 3,5-Bis(hydroxymethyl)phenol
  • [3-hexadecoxy-5-(hydroxymethyl)phenyl]methanol

Customs

[ HS Code ]: 2918290000

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

Articles

Application of stripping voltammetry to trace lead analysis in intermediates and final products of syntheses of pharmaceuticals.

J. Pharm. Biomed. Anal. 14(7) , 765-71, (1996)

Applications of differential pulse anodic stripping voltammetry using a new pen-type renewed hanging mercury electrode have been investigated for trace analysis of lead in pharmaceutical substances an...

[Information from the Soviet Toxicology Center].

Gig. Tr. Prof. Zabol. (2) , 52-3, (1983)

Two 3D chiral coordination polymers with 4-connected 6(6) topological net: synthesis, structure and magnetic properties.

Dalton Trans. (44) , 9807-11, (2009)

The hydrothermal reaction of Co(II)/Cu(II), 5-hydroxyisophthalic acid and dipyridophenazine leads to the generation of two 3D chiral coordination polymers, [M(hip)(DPPZ)](n) (M = Co(), Cu(), H(2)hip =...


More Articles

Related Compounds

  • 5-Hydroxyisophthalic Acid Dimethyl Ester
  • 5-hydroxyisophthalic acid monomethyl ester
  • diethyl ester of 5-hydroxyisophthalic acid
  • 5-(TERT-BUTYL)-2-HYDROXYISOPHTHALIC ACID
  • 5-aminoacetamido-4,6-dimethyl-2-hydroxyisophthalic acid diethyl ester
  • 4-hydroxyisophthalic acid, compound with 4-amino-1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one (1:1)
  • 5-bromo-2,3,4,9-tetrahydro-1H-carbazol-1-one
  • Methyl 4-(piperidin-4-yl)oxane-4-carboxylate hydrochloride
  • 5-bromo-6-fluoro-3,3-dimethyl-2,3-dihydro-1H-indole hydrochloride
  • 2-(4-Iodo-1-methyl-1H-pyrazol-3-yl)piperidine hydrochloride
  • 2-(4-iodo-1-methyl-1H-pyrazol-3-yl)piperidine
  • 2-Methylpent-4-yn-2-amine hydrochloride
  • Tert-butyl n-(3-amino-1-methylcyclobutyl)carbamate hydrochloride
  • (2,3-Dimethyl-2,3-dihydro-1-benzofuran-5-yl)methanamine hydrochloride
  • 2-(tert-Butoxycarbonyl)isoxazolidine-5-carboxylic acid
  • 4-(Trifluoromethyl)-5h,7h,8h-pyrano[4,3-c]pyridazin-3-ol