2-Chloro-4-nitrophenol

Names

[ CAS No. ]:
619-08-9

[ Name ]:
2-Chloro-4-nitrophenol

[Synonym ]:
2-Chloro-4-nitrophenol
Phenol, 2-chloro-4-nitro-
3-Carboxybenzaldehyde
EINECS 210-578-8
MFCD00043910
2-Chlor-4-nitrobenzolol

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
290.6±25.0 °C at 760 mmHg

[ Melting Point ]:
106 °C

[ Molecular Formula ]:
C₆H₄ClNO₃

[ Molecular Weight ]:
173.554

[ Flash Point ]:
129.6±23.2 °C

[ Exact Mass ]:
172.987976

[ PSA ]:
66.05000

[ LogP ]:
2.22

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.627

[ Water Solubility ]:
slightly soluble

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SK5075000

CHEMICAL NAME :: Phenol, 2-chloro-4-nitro-

CAS REGISTRY NUMBER :: 619-08-9

BEILSTEIN REFERENCE NO. :: 2046372

LAST UPDATED :: 199710

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C6-H4-Cl-N-O3

MOLECULAR WEIGHT :: 173.56

WISWESSER LINE NOTATION :: WNR DQ CG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0570573

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 18,868,1975

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0570573

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H315-H319-H332-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
2811

[ WGK Germany ]:
3

[ RTECS ]:
SK5075000

[ HS Code ]:
29089000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-Chlorophenol
4-Nitrophenol
3-Nitrochlorobenzene
1,2-Dichloro-4-nitrobenzene
dichloronitrobenzene
4-Nitrosophenol
2-Bromo-6-chloro-4-nitro-phenol
4-Bromo-2-chlorophenol
methyl 2-chloro-4-nitrophenyl phosphate

DownStream

3-Chloro-4-[(pyridin-2-yl)methyloxy]aniline
2-Chloro-4-nitrophenyl 2,3,4,6-tetra-O-acetyl-b-D-glucopyranoside
2-Chloro-4-nitroanisole
2-Chloro-4-nitrophenyl 3-fluorobenzyl ether
4-Benzyloxy-3-chloronitrobenzene
N-(3-Chloro-4-hydroxyphenyl)acetamide
2-CHLORO-4,6-DINITROPHENOL
2-Amino-4-chlorophenol
Benzene,2-chloro-4-nitro-1-(4-phenoxybutoxy)-
Benzonitrile,4-[4-(2-chloro-4-nitrophenoxy)butoxy]-

Customs

[ HS Code ]: 2908999090

[ Summary ]:
2908999090 halogenated, sulphonated, nitrated or nitrosated derivatives of phenols or phenol-alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

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