Proadifen hydrochloride
Suppliers
Names
[ CAS No. ]:
62-68-0
[ Name ]:
Proadifen hydrochloride
[Synonym ]:
Benzeneacetic acid, α-phenyl-α-propyl-, 2-(diethylamino)ethyl ester, hydrochloride (1:1)
2-Diethylaminoethyl Propyldiphenylacetate Hydrochloride
β-Diethylaminoethyl diphenylpropylacetate hydrochloride
F 525-A
SKF-525A,Hydrochloride
RP 5171
2-Diethylaminoethyl α,α-diphenyl valerate hydrochloride
2,2-Diphenylvaleric Acid 2-(Diethylamino)ethyl Ester Hydrochloride
2-[(2,2-diphenylpentanoyl)oxy]-N,N-diethylethanaminium chloride
Benzeneacetic acid, α-phenyl-α-propyl-, 2- (diethylamino)ethyl ester, hydrochloride
Proadifen HCl
Proadifen hydrochloride
proadifen
2-Diethylaminoethyl-2,2-diphenylvalerate Hydrochloride
N,N-diethylaminoethyl-2,2-diphenylvalerate hydrochloride
Valeric acid, 2,2-diphenyl-, 2-diethylaminoethyl ester, hydrochloride
SKF 525A
Valeric acid, 2,2-diphenyl-, 2- (diethylamino)ethyl ester hydrochloride
Benzeneacetic acid, α-phenyl-α-propyl-, 2-(diethylamino)ethyl ester hydrochloride
2-diethylaminoethyl 2,2-diphenylvalerate hydrochloride
MFCD00055151
Propyladiphenin
2-(Diethylamino)ethyl 2,2-diphenylpentanoate hydrochloride (1:1)
a-Phenyl-a-propylbenzeneacetic Acid 2-(Diethylamino)ethyl Ester Hydrochloride
SKF-525A
Chemical & Physical Properties
[ Boiling Point ]:
460.8ºC at 760 mmHg
[ Melting Point ]:
122-123ºC
[ Molecular Formula ]:
C23H32ClNO2
[ Molecular Weight ]:
389.959
[ Flash Point ]:
132.3ºC
[ Exact Mass ]:
389.212158
[ PSA ]:
29.54000
[ LogP ]:
5.45980
[ Storage condition ]:
−20°C
[ Stability ]:
Store in Freezer
[ Water Solubility ]:
Soluble in methanol or water
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- YV7175000
- CHEMICAL NAME :
- Valeric acid, 2,2-diphenyl-, 2-(diethylamino)ethyl ester, hydrochloride
- CAS REGISTRY NUMBER :
- 62-68-0
- LAST UPDATED :
- 199206
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C23-H31-N-O2.Cl-H
- MOLECULAR WEIGHT :
- 390.01
- WISWESSER LINE NOTATION :
- 3XR&R&VO2N2&2 &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2140 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 111,131,1954
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 163 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,366,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 538 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 111,131,1954
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 110 mg/kg
- TOXIC EFFECTS :
- Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - reactivates cholinesterase
- REFERENCE :
- PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 3,508,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 60 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,366,1972
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- >100 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Gastrointestinal - nausea or vomiting
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 8,118,1966
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 8,118,1966
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- >10 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 8,118,1966 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 20 mg/kg
- SEX/DURATION :
- female 4 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina
- REFERENCE :
- JSICAZ Journal of Scientific and Industrial Research, Section C: Biological Sciences. (New Delhi, India) V.14-21, 1955-62. For publisher information, see IJEBA6. Volume(issue)/page/year: 19,264,1960
Safety Information
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn
[ Risk Phrases ]:
22
[ Safety Phrases ]:
S36
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
YV7175000
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