1,4-Bis(chloromethyl)benzene

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Names

[ CAS No. ]:
623-25-6

[ Name ]:
1,4-Bis(chloromethyl)benzene

[Synonym ]:
MFCD00000920
G1R D1G
1,4-Bis(chloromethyl)-benzene
1,4-Bis(chloromethyl)benzene
EINECS 210-782-7

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
242.5±0.0 °C at 760 mmHg

[ Melting Point ]:
98-101 °C(lit.)

[ Molecular Formula ]:
C8H8Cl2

[ Molecular Weight ]:
175.055

[ Flash Point ]:
119.2±15.1 °C

[ Exact Mass ]:
174.000305

[ LogP ]:
2.76

[ Vapour Pressure ]:
0.1±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.545

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
hydrolysis

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ZE4100000
CHEMICAL NAME :
p-Xylene, alpha,alpha'-dichloro-
CAS REGISTRY NUMBER :
623-25-6
BEILSTEIN REFERENCE NO. :
0774706
LAST UPDATED :
199712
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C8-H8-Cl2
MOLECULAR WEIGHT :
175.06
WISWESSER LINE NOTATION :
G1R D1G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1280 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
501 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Liver - other changes

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
100 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 191,79,1987

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H410

[ Precautionary Statements ]:
P273-P305 + P351 + P338-P501

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
T+:Verytoxic;

[ Risk Phrases ]:
R22;R26;R36/37/38

[ Safety Phrases ]:
S26-S36/37-S45-S36/37/39-S28A

[ RIDADR ]:
3261

[ WGK Germany ]:
3

[ RTECS ]:
ZE4100000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

[ HS Code ]:
29036990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Formaldehyde
  • benzene
  • p-Xylene
  • 1,4-Phenylenedimethylene bis(chloroformate)
  • Benzyl chloride
  • Toluene
  • BIS(CHLOROMETHYL) ETHER
  • 1,4-Benzenedimethanol
  • 4-Methylbenzyl chloride
  • N-chlorosuccinimide

DownStream

  • p-Xylene-.alpha.,.alpha.-diol, dimethanesulfonate
  • [2,2,2]-paracyclophane
  • [24]paracyclophane
  • 1,2-di(p-tolyl)ethane
  • 1,4-bis[2-(4-methylphenyl)ethyl]benzene
  • 1,2-Benzenedicarboxylicacid, 4,4'-(1,4-phenylenedicarbonyl)bis- (9CI)
  • Diethyl (4-chloromethyl)benzylphosphonate
  • Benzene,1,4-bis(iodomethyl)
  • 2-[[4-(chloromethyl)phenyl]methyl]isoindole-1,3-dione
  • 1H-Isoindole-1,3(2H)-dione,2,2'-[1,4-phenylenebis(methylene)]bis- (9CI)

Customs

[ HS Code ]: 2903999090

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Effects of quaternization on the morphological stability and antibacterial activity of electrospun poly(DMAEMA-co-AMA) nanofibers.

Colloids Surf. B Biointerfaces 133 , 148-55, (2015)

Electrospun nanofibers with antibacterial activity are greatly promising for medical treatment and water purification. Herein we report antibacterial nanofibers electrospun from a series of poly(dimet...

Contact dermatitis caused by "chloromethyl heterocyclic intermediates".

Contact Dermatitis 16(1) , 52, (1987)

Preparation of PPV nanotubes and nanorods and carbonized products derived therefrom. Kim K and Jin J.

Nano Lett. 1(11) , 205-210, (1981)


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Related Compounds

  • 7-(4-bromophenyl)-N-(2-methoxybenzyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
  • Ethyl 4-hydroxy-6-(2-hydroxyphenyl)-2-oxo-4-(trifluoromethyl)-1,3-diazinane-5-carboxylate
  • 2-[(3-Chlorophenyl)methylsulfanyl]-9-methylpyrido[1,2-a][1,3,5]triazin-4-one
  • N-(5-chloro-2-methoxyphenyl)-2-(3-oxopiperazin-2-yl)acetamide
  • (Z)-ethyl 2-(2-((4-oxo-4H-chromene-2-carbonyl)imino)-6-sulfamoylbenzo[d]thiazol-3(2H)-yl)acetate
  • 3-(4-bromophenyl)-1-(methylsulfonyl)-5-(p-tolyl)-4,5-dihydro-1H-pyrazole
  • N-(4-fluorophenyl)-2-((2-phenyl-4-tosyloxazol-5-yl)thio)acetamide
  • N-[2-(4-methoxyphenyl)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-3,4-dimethylbenzamide
  • N-(2,3-dimethylphenyl)-2-[3-oxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetamide
  • 2-imino-N,8-dimethyl-5-oxo-1-propan-2-yl-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide
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