1-MONONITROGLYCERIN

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Names

[ CAS No. ]:
624-43-1

[ Name ]:
1-MONONITROGLYCERIN

[Synonym ]:
1,2,3-Propanetriol,1-nitrate
Glycerol-1-nitrate
Glycerol-1-nitrat
glyceryl 1-mononitrate
Glycerol 1-mononitrate
glycerol nitrate
propylene glycol 1-nitrate
Glycerol-1-mononitrat
1-Mononitroglycerin
1-Mononitroglycerol

Chemical & Physical Properties

[ Molecular Formula ]:
C₃H₇NO₅

[ Molecular Weight ]:
137.09100

[ Exact Mass ]:
137.03200

[ PSA ]:
95.51000

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MB0200000

CHEMICAL NAME :: Glycerol, 1-nitrate

CAS REGISTRY NUMBER :: 624-43-1

BEILSTEIN REFERENCE NO. :: 1761580

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C3-H7-N-O5

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 339 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD-B011-150

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 580 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,814,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1433 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD-B011-150

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3160 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,814,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,814,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,814,1986

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H302 + H312 + H332-H319

[ Precautionary Statements ]:
P210-P261-P302 + P352 + P312-P304 + P340 + P312-P337 + P313-P403 + P235

[ RIDADR ]:
UN 1648 3 / PGII

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Glycerol
3-BROMO-1,2-PROPANEDIOL
Glycidol
ALLYLNITRATE
Nitroglycerin
1,3-DINITROGLYCERIN
1,2-DINITROGLYCERIN
nitric acid
1,4-Dioxane
2,2,4-Trimethylpentane

DownStream

Glycerol
1,3-DINITROGLYCERIN

Articles

Studies on the biphasic relaxant curve of glyceryl trinitrate in rat aorta: role of GTN metabolites.

Clin. Exp. Pharmacol. Physiol. 16(11) , 829-35, (1989)

1. The present study has examined the possibility that one or more metabolites of glyceryl trinitrate (GTN) (i.e. glyceryl-1,2- and -1,3-dinitrate and glyceryl-1- and -2-mononitrate) may be responsibl...

Guanylate cyclase activation by organic nitrates is not mediated via nitrite.

J. Mol. Cell. Cardiol. 20(5) , 389-96, (1988)

Nitrovasodilators relax vascular smooth muscle by stimulating guanylate cyclase. Ignarro et al. (1981) proposed a mechanistic scheme according to which organic nitrates release nitrite in the presence...

[Comparative pharmacology of glycerol-1-nitrate and glyceryl trinitrate in various species].

Arzneimittelforschung 36(5) , 814-21, (1986)

The present studies yield that all 4 metabolites of glyceryl trinitrate (Nitro Mack, GTN) cause the same typical pharmacological effects as the parent substance. Continuous infusion of 4 mg/kg/min of ...

1-Mononitroglycerin
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