1-MONONITROGLYCERIN

Modify Date: 2024-01-02 15:24:25

1-MONONITROGLYCERIN Structure
1-MONONITROGLYCERIN structure
 Common Name 1-MONONITROGLYCERIN
CAS Number 624-43-1 Molecular Weight 137.09100
Density N/A Boiling Point N/A
Molecular Formula C3H7NO5 Melting Point N/A
MSDS N/A Flash Point 35.6 °F
Symbol GHS02 GHS07
GHS02, GHS07		 Signal Word Danger

 Names

Name 2,3-dihydroxypropyl nitrate
Synonym More Synonyms

 Chemical & Physical Properties

Molecular Formula C3H7NO5
Molecular Weight 137.09100
Exact Mass 137.03200
PSA 95.51000

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MB0200000
CHEMICAL NAME :
Glycerol, 1-nitrate
CAS REGISTRY NUMBER :
624-43-1
BEILSTEIN REFERENCE NO. :
1761580
LAST UPDATED :
199612
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C3-H7-N-O5

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
339 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD-B011-150
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
580 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,814,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1433 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD-B011-150
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3160 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,814,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,814,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,814,1986

 Safety Information

Symbol GHS02 GHS07
GHS02, GHS07
Signal Word Danger
Hazard Statements H225-H302 + H312 + H332-H319
Precautionary Statements P210-P261-P302 + P352 + P312-P304 + P340 + P312-P337 + P313-P403 + P235
RIDADR UN 1648 3 / PGII
Flash Point(F) 35.6 °F
Flash Point(C) 2 °C

 Synthetic Route

 Articles8

More Articles
Studies on the biphasic relaxant curve of glyceryl trinitrate in rat aorta: role of GTN metabolites.

Clin. Exp. Pharmacol. Physiol. 16(11) , 829-35, (1989)

1. The present study has examined the possibility that one or more metabolites of glyceryl trinitrate (GTN) (i.e. glyceryl-1,2- and -1,3-dinitrate and glyceryl-1- and -2-mononitrate) may be responsibl...

Guanylate cyclase activation by organic nitrates is not mediated via nitrite.

J. Mol. Cell. Cardiol. 20(5) , 389-96, (1988)

Nitrovasodilators relax vascular smooth muscle by stimulating guanylate cyclase. Ignarro et al. (1981) proposed a mechanistic scheme according to which organic nitrates release nitrite in the presence...

[Comparative pharmacology of glycerol-1-nitrate and glyceryl trinitrate in various species].

Arzneimittelforschung 36(5) , 814-21, (1986)

The present studies yield that all 4 metabolites of glyceryl trinitrate (Nitro Mack, GTN) cause the same typical pharmacological effects as the parent substance. Continuous infusion of 4 mg/kg/min of ...

 Synonyms

1,2,3-Propanetriol,1-nitrate
Glycerol-1-nitrate
Glycerol-1-nitrat
glyceryl 1-mononitrate
Glycerol 1-mononitrate
glycerol nitrate
propylene glycol 1-nitrate
Glycerol-1-mononitrat
1-Mononitroglycerin
1-Mononitroglycerol
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