FORMAMIDOXIME

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Names

[ CAS No. ]:
624-82-8

[ Name ]:
FORMAMIDOXIME

[Synonym ]:
EINECS 210-865-8
carboxamidoxime
Aminoformaldehyde oxime
formamideoxime
N-hydroxycarboximidamide
n-hydroxy-methanimidamid
formamidoxim
n-hydroxymethanimidamide
isuretin
MFCD00008125
isouretin

Chemical & Physical Properties

[ Density]:
1.29g/cm3

[ Boiling Point ]:
224ºC at 760 mmHg

[ Melting Point ]:
112-115ºC(lit.)

[ Molecular Formula ]:
CH4N2O

[ Molecular Weight ]:
60.05530

[ Flash Point ]:
89.3ºC

[ Exact Mass ]:
60.03240

[ PSA ]:
58.61000

[ LogP ]:
0.06290

[ Index of Refraction ]:
1.471

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LQ4632000
CHEMICAL NAME :
Formamidoxime
CAS REGISTRY NUMBER :
624-82-8
LAST UPDATED :
199304
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C-H4-N2-O
MOLECULAR WEIGHT :
60.07
WISWESSER LINE NOTATION :
QM1UM

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,645,1968

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H312 + H332-H351

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
20/21/22-40

[ Safety Phrases ]:
22-36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
LQ4632000

[ HS Code ]:
2925290090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • POTASSIUM CYANIDE
  • HYDROGEN CYANIDE
  • Hydroxylamine
  • Ethanol
  • Diethyl ether
  • Water
  • methyl methanimidate,hydrochloride
  • Ethoxymethaniminium chloride

DownStream

  • Formic Acid
  • Ammonia
  • Hydroxylamine
  • acetylurea
  • Biuret
  • Carbonic acid
  • (aminomethylideneamino) benzoate
  • Dibenzohydroxamic acid
  • formonitrile oxide
  • silver fulminate

Customs

[ HS Code ]: 2925290090

[ Summary ]:
2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Antitumor activity of amidoximes (hydroxyurea analogs) in murine tumor systems.

Cancer Res. 38(5) , 1291-5, (1978)

A series of amidoximes was prepared and evaluated for possible antitumor activity against L1210 leukemia. Three of the most active compounds in the L1210 system, formamidoxime, acetamidoxime, and 2-am...

Nitric oxide synthesis by tracheal smooth muscle cells by a nitric oxide synthase-independent pathway.

Am. J. Physiol. 275(5 Pt 1) , L895-901, (1998)

Nitric oxide (NO) is known to be synthesized from L-arginine in a reaction catalyzed by NO synthase. Liver cytochrome P-450 enzymes also catalyze the oxidative cleavage of C==N bonds of compounds cont...

Effects of phenobarbital, beta-naphthoflavone, dexamethasone, and formamidoxime on the turnover of inducible microsomal proteins in cultured hepatocytes.

J. Biol. Chem. 256(24) , 13079-84, (1981)

Microsomal proteins from cultured chick embryo hepatocytes were separated by polyacrylamide gel electrophoresis and their rate constants of degradation (Kd) were estimated using double isotope techniq...


More Articles

Related Compounds

  • 1-Morpholino-formamidoxime
  • N-(3-phenylpropyl)formamidoxime
  • N-(5-bromopyrid-2-yl)formamidoxime
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • 5-methyl-2-oxo-1H-pyridine-4-carbaldehyde
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide