2-Crotonoyl chloride

Names

[ CAS No. ]:
625-35-4

[ Name ]:
2-Crotonoyl chloride

[Synonym ]:
2-Butenoyl chloride, (2E)-
(2E)-2-Butenoyl chloride
(E)-2-Butenoyl chloride
MFCD00000734
(2E)-But-2-enoylchlorid
2-Crotonoyl chloride
EINECS 234-010-3
(2E)-But-2-enoyl chloride

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
124.5±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄H₅ClO

[ Molecular Weight ]:
104.535

[ Flash Point ]:
35.0±0.0 °C

[ Exact Mass ]:
104.002892

[ PSA ]:
17.07000

[ LogP ]:
1.58

[ Vapour Pressure ]:
12.7±0.2 mmHg at 25°C

[ Index of Refraction ]:
1.441

[ Storage condition ]:
2-8°C

MSDS

Safety Information

[ Symbol ]:

GHS02, GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H226-H314-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C:Corrosive

[ Risk Phrases ]:
R10;R34

[ Safety Phrases ]:
S16-S24/25-S28

[ RIDADR ]:
UN 2920

[ WGK Germany ]:
3

[ Packaging Group ]:
II

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

hexa-1,4-dien-3-one
3-Methylindanone
Methyl 3-butenoate
Methyl (2E)-2-butenoate
3,7-dimethyl-2,3-dihydroinden-1-one
3,5-DIMETHYLINDAN-1-ONE
Locostatin
(S)-(+)-(2-BUTENOYL)-2 10-CAMPHORSULTAM
p-Tolyl Crotonate
2-Butenamide,N,N-diethyl-, (2E)-

Articles

Double asymmetric induction as a mechanistic probe: the doubly diastereoselective conjugate addition of enantiopure lithium amides to enantiopure α,β-unsaturated esters and enantiopure α,β-unsaturated hydroxamates. Davies SG, et al.

Tetrahedron 67(34) , 6382-6403, (2011)