Lactose

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Names

[ CAS No. ]:
63-42-3

[ Name ]:
Lactose

[Synonym ]:
b-Lactose
β-Lactose
SUGAR MILK
EINECS 200-559-2
b-D-glucopyranose, 4-O-b-D-galactopyranosyl-
LACTOBIOSE
Aletobiose
D-LACTOSE
LACTIN
4-O-b-D-galactopyranosyl-b-D-glucopyranose
Lactose (8CI)
Lactose
4-O-β-D-Galactopyranosyl-β-D-glucopyranose
Osmolactan
Galactinum
β-D-Glucopyranose, 4-O-β-D-galactopyranosyl-
4-(b-D-Galactosido)-D-glucose
MFCD00151251

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
667.9±55.0 °C at 760 mmHg

[ Melting Point ]:
222.8°C

[ Molecular Formula ]:
C12H22O11

[ Molecular Weight ]:
342.297

[ Flash Point ]:
357.8±31.5 °C

[ Exact Mass ]:
342.116211

[ PSA ]:
197.37000

[ LogP ]:
-3.41

[ Vapour Pressure ]:
0.0±4.6 mmHg at 25°C

[ Index of Refraction ]:
1.652

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
5-10 g/100 mL at 20 ºC

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OD9625000
CHEMICAL NAME :
Lactose
CAS REGISTRY NUMBER :
63-42-3
BEILSTEIN REFERENCE NO. :
0093796
LAST UPDATED :
199701
DATA ITEMS CITED :
12
MOLECULAR FORMULA :
C12-H22-O11
MOLECULAR WEIGHT :
342.34
WISWESSER LINE NOTATION :
T6OTJ BQ CQ DQ F1Q EO- BT6OTJ CQ DQ EQ F1Q -D

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 3,2427,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 3,2427,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 3,2427,1975
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4452 gm/kg/53W-C
TOXIC EFFECTS :
Gastrointestinal - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 11,165,1992
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
41 gm/kg/26W-C
TOXIC EFFECTS :
Cardiac - changes in heart weight Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 11,219,1992 ** TUMORIGENIC DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1000 gm/kg/29w-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher information, see JJCREP. Volume(issue)/page/year: 46,363,1955 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
375 mg/kg
SEX/DURATION :
female 4-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 4,497,1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81715 No. of Facilities: 3594 (estimated) No. of Industries: 19 No. of Occupations: 35 No. of Employees: 26586 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9297 No. of Facilities: 78 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1207 (estimated) No. of Female Employees: 922 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81715 No. of Facilities: 4424 (estimated) No. of Industries: 33 No. of Occupations: 51 No. of Employees: 132323 (estimated) No. of Female Employees: 76197 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
OD9625000

[ HS Code ]:
1702190000

Synthetic Route

Precursor & DownStream

Precursor

  • β-D-Glucopyranose
  • α-D-CELLOBIOSE OCTAACETATE
  • 2,3,4,6-Tetra-O-acetyl-alpha-D-galactopyranosyl bromide
  • N-(1-ethoxycarbonyl-propen-2-yl)urea
  • acetic acid
  • 2'-Fucosyllactose
  • Hydrochloric acid
  • Tartaric acid

DownStream

  • hexane-1,2,5-triol
  • α-D-CELLOBIOSE OCTAACETATE
  • D-Gluconic acid
  • Gluconic acid
  • Mucic acid
  • Saccharic acid
  • 2-ACETAMIDO-2-DEOXY-3-O-(BETA-D-GALACTOPYRANOSYL)-D-GLUCOPYRANOSE
  • Acetoin
  • Lactulose
  • (2R,3R)-(-)-2,3-Butanediol

Customs

[ HS Code ]: 1702190000

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Related Compounds

  • Lactose
  • Lactose
  • Lactose
  • D-Lactose
  • D-LACTOSE
  • LACTOSE BP