Lactose

Modify Date: 2024-01-02 22:14:39

Lactose Structure
Lactose structure
 Common Name Lactose
CAS Number 63-42-3 Molecular Weight 342.297
Density 1.8±0.1 g/cm3 Boiling Point 667.9±55.0 °C at 760 mmHg
Molecular Formula C12H22O11 Melting Point 222.8°C
MSDS USA Flash Point 357.8±31.5 °C

 Use of Lactose


Lactose, a major sugar in the milk of most species, could regulate human’s intestinal microflora.

 Names

Name lactose
Synonym More Synonyms

 Lactose Biological Activity

Description Lactose, a major sugar in the milk of most species, could regulate human’s intestinal microflora.
Related Catalog
Target

Human Endogenous Metabolite

References

[1]. Kleessen B, et al. Effects of inulin and lactose on fecal microflora, microbial activity, and bowel habit in elderly constipated persons. Am J Clin Nutr. 1997 May;65(5):1397-402.

 Chemical & Physical Properties

Density 1.8±0.1 g/cm3
Boiling Point 667.9±55.0 °C at 760 mmHg
Melting Point 222.8°C
Molecular Formula C12H22O11
Molecular Weight 342.297
Flash Point 357.8±31.5 °C
Exact Mass 342.116211
PSA 197.37000
LogP -3.41
Vapour Pressure 0.0±4.6 mmHg at 25°C
Index of Refraction 1.652
Stability Stable. Incompatible with strong oxidizing agents.
Water Solubility 5-10 g/100 mL at 20 ºC

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OD9625000
CHEMICAL NAME :
Lactose
CAS REGISTRY NUMBER :
63-42-3
BEILSTEIN REFERENCE NO. :
0093796
LAST UPDATED :
199701
DATA ITEMS CITED :
12
MOLECULAR FORMULA :
C12-H22-O11
MOLECULAR WEIGHT :
342.34
WISWESSER LINE NOTATION :
T6OTJ BQ CQ DQ F1Q EO- BT6OTJ CQ DQ EQ F1Q -D

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 3,2427,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 3,2427,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 3,2427,1975
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4452 gm/kg/53W-C
TOXIC EFFECTS :
Gastrointestinal - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 11,165,1992
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
41 gm/kg/26W-C
TOXIC EFFECTS :
Cardiac - changes in heart weight Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 11,219,1992 ** TUMORIGENIC DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1000 gm/kg/29w-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher information, see JJCREP. Volume(issue)/page/year: 46,363,1955 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
375 mg/kg
SEX/DURATION :
female 4-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 4,497,1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81715 No. of Facilities: 3594 (estimated) No. of Industries: 19 No. of Occupations: 35 No. of Employees: 26586 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9297 No. of Facilities: 78 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1207 (estimated) No. of Female Employees: 922 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81715 No. of Facilities: 4424 (estimated) No. of Industries: 33 No. of Occupations: 51 No. of Employees: 132323 (estimated) No. of Female Employees: 76197 (estimated)

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS OD9625000
HS Code 1702190000

 Synthetic Route

β-D-Glucopyranose structure

β-D-Glucopyranose

CAS#:492-61-5

~%

Lactose Structure

Lactose

CAS#:63-42-3

Literature: Helvetica Chimica Acta, , vol. 11, p. 209
α-D-CELLOBIOSE OCTAACETATE structure

α-D-CELLOBIOSE ...

CAS#:3616-19-1

~%

Lactose Structure

Lactose

CAS#:63-42-3

Literature: Journal of the American Chemical Society, , vol. 64, p. 1852,1854
2,3,4,6-Tetra-O-acetyl-alpha-D-galactopyranosyl bromide structure

2,3,4,6-Tetra-O...

CAS#:3068-32-4

~%

Lactose Structure

Lactose

CAS#:63-42-3

Literature: Canadian Journal of Chemistry, , vol. 37, p. 358
β-D-Glucopyranose structure

β-D-Glucopyranose

CAS#:492-61-5

N-(1-ethoxycarbonyl-propen-2-yl)urea structure

N-(1-ethoxycarb...

CAS#:5435-44-9

~%

Lactose Structure

Lactose

CAS#:63-42-3

Literature: Helvetica Chimica Acta, , vol. 11, p. 209
acetic acid structure

acetic acid

CAS#:64-19-7

2'-Fucosyllactose structure

2'-Fucosyllactose

CAS#:41263-94-9

~%

Fucose structure

Fucose

CAS#:2438-80-4

Lactose Structure

Lactose

CAS#:63-42-3

Literature: Biochemical Journal, , vol. 68, p. 708,710, 713 Chemische Berichte, , vol. 88, p. 1145
Hydrochloric acid structure

Hydrochloric acid

CAS#:7647-01-0

2'-Fucosyllactose structure

2'-Fucosyllactose

CAS#:41263-94-9

~%

Fucose structure

Fucose

CAS#:2438-80-4

Lactose Structure

Lactose

CAS#:63-42-3

Literature: Biochemical Journal, , vol. 68, p. 708,710, 713 Chemische Berichte, , vol. 88, p. 1145
N/A structure

N/A

CAS#:909878-64-4

Tartaric acid structure

Tartaric acid

CAS#:87-69-4

~%

5-Deoxyinositol structure

5-Deoxyinositol

CAS#:488-73-3

sucrose structure

sucrose

CAS#:57-50-1

Detail
Literature: Annales de Chimie (Cachan, France), , vol. <3>54, p. 78

 Customs

HS Code 1702190000

 Articles183

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 Synonyms

b-Lactose
β-Lactose
SUGAR MILK
EINECS 200-559-2
b-D-glucopyranose, 4-O-b-D-galactopyranosyl-
LACTOBIOSE
Aletobiose
D-LACTOSE
LACTIN
4-O-b-D-galactopyranosyl-b-D-glucopyranose
Lactose (8CI)
Lactose
4-O-β-D-Galactopyranosyl-β-D-glucopyranose
Osmolactan
Galactinum
β-D-Glucopyranose, 4-O-β-D-galactopyranosyl-
4-(b-D-Galactosido)-D-glucose
MFCD00151251
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