Pifithrin-α hydrobromide

Suppliers

Names

[ Name ]:
Pifithrin-α hydrobromide

[Synonym ]:
Pifithrin-α hydrobromide
Pifithrin-a
1-(4-methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)- benzothiazolyl)ethanone hydrobromide
2-imino-3-phenacyl-4,5,6,7-tetrahydrobenzothiazole hydrobromide
PFT-α
Pifithrin-α
PFTalpha
Pifithrin-|A
Ethanone, 1-(4-methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)-, hydrobromide (1:1)
2-(2-Imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3(2H)-yl)-1-(4-methylphenyl)ethanone hydrobromide (1:1)
Pifithrin-Alpha
MFCD00417851
Pifithrin-Alpha (hydrobromide)
Pifithrin-α (hydrobromide)
Pifithrin

Chemical & Physical Properties

[ Density]:
1.28g/cm3

[ Boiling Point ]:
456.8ºC at 760 mmHg

[ Melting Point ]:
192.1-192.5ºC(lit.)

[ Molecular Formula ]:
C₁₆H₁₉BrN₂OS

[ Molecular Weight ]:
367.304

[ Flash Point ]:
230.1ºC

[ Exact Mass ]:
366.040131

[ PSA ]:
74.09000

[ LogP ]:
4.15700

[ Appearance of Characters ]:
powder

[ Index of Refraction ]:
1.666

[ Storage condition ]:
−20°C

[ Water Solubility ]:
DMSO: 20 mg/mL

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy.

Science 285 , 1733-1737, (1999)

Chemotherapy and radiation therapy for cancer often have severe side effects that limit their efficacy. Because these effects are in part determined by p53-mediated apoptosis, temporary suppression of...

Suppression of p53: a new approach to overcome side effects of antitumor therapy.

Biochemistry 65 , 41-48, (2000)

The p53 protein is traditionally believed to be a tumor suppressor. Activation of p53-dependent apoptosis in response to damage to cell DNA provides for the elimination of possible tumor cell precurso...

p53 protein-mediated up-regulation of MAP kinase phosphatase 3 (MKP-3) contributes to the establishment of the cellular senescent phenotype through dephosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2).

J. Biol. Chem. 290(2) , 1129-40, (2015)

Growth arrest is one of the essential features of cellular senescence. At present, the precise mechanisms responsible for the establishment of the senescence-associated arrested phenotype are still in...