Pifithrin-α hydrobromide
Pifithrin-α hydrobromide structure
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Common Name | Pifithrin-α hydrobromide | ||
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| CAS Number | 63208-82-2 | Molecular Weight | 367.304 | |
| Density | 1.28g/cm3 | Boiling Point | 456.8ºC at 760 mmHg | |
| Molecular Formula | C16H19BrN2OS | Melting Point | 192.1-192.5ºC(lit.) | |
| MSDS | USA | Flash Point | 230.1ºC | |
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A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy.
Science 285 , 1733-1737, (1999) Chemotherapy and radiation therapy for cancer often have severe side effects that limit their efficacy. Because these effects are in part determined by p53-mediated apoptosis, temporary suppression of p53 has been suggested as a therapeutic strategy to preven... |
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Suppression of p53: a new approach to overcome side effects of antitumor therapy.
Biochemistry 65 , 41-48, (2000) The p53 protein is traditionally believed to be a tumor suppressor. Activation of p53-dependent apoptosis in response to damage to cell DNA provides for the elimination of possible tumor cell precursors. However, in some cases the activity of p53 can be dange... |
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p53 protein-mediated up-regulation of MAP kinase phosphatase 3 (MKP-3) contributes to the establishment of the cellular senescent phenotype through dephosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2).
J. Biol. Chem. 290(2) , 1129-40, (2015) Growth arrest is one of the essential features of cellular senescence. At present, the precise mechanisms responsible for the establishment of the senescence-associated arrested phenotype are still incompletely understood. Given that ERK1/2 is one of the majo... |