Berberine hydrochloride
Suppliers
Names
[ CAS No. ]:
633-65-8
[ Name ]:
Berberine hydrochloride
[Synonym ]:
1,3-Benzodioxolo[5,6-a]benzo[g]quinolizinium, 5,6-dihydro-9,10-dimethoxy-, hydrochloride (1:1)
EINECS 211-195-9
berberine hydrochloride
BERBERINE HCL
5,6-dihydro-9,10-dimethoxy-1,3-benzodioxolo[5,6-a]benzo[g]quinolizinium chloride (1:1)
MFCD00011939
9,10-dimethoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium chloride
Berberine (chloride)
Chemical & Physical Properties
[ Density]:
1.654g/cm3
[ Melting Point ]:
200ºC
[ Molecular Formula ]:
C20H18ClNO4
[ Molecular Weight ]:
372.822
[ Exact Mass ]:
372.099701
[ PSA ]:
40.80000
[ LogP ]:
0.10030
[ Water Solubility ]:
SOLUBLE IN COLD WATER
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DR9866400
- CHEMICAL NAME :
- Berbinium, 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylene dioxy)-, chloride
- CAS REGISTRY NUMBER :
- 633-65-8
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C20-H18-N-O4.Cl
- MOLECULAR WEIGHT :
- 371.84
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >15 gm/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - body temperature decrease
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 60 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >29586 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - body temperature decrease
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 37 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 30 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- DNA damage
- TEST SYSTEM :
- Mammal - species unspecified Lymphocyte
- DOSE/DURATION :
- 22 umol/L
- REFERENCE :
- IJBBBQ Indian Journal of Biochemistry and Biophysics. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.8- 1971- Volume(issue)/page/year: 18,245,1981
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
Xn: Harmful;
[ Risk Phrases ]:
R20/21/22
[ Safety Phrases ]:
S24/25
[ RIDADR ]:
UN 1544
[ WGK Germany ]:
2
[ RTECS ]:
DR9866400
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
[ HS Code ]:
3003409000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 3003409000
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