Foscarnet sodium

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Names

[ CAS No. ]:
63585-09-1

[ Name ]:
Foscarnet sodium

[Synonym ]:
Phosphoranecarboxylic acid, 1,1-dihydroxy-, oxide, sodium salt (1:3)
Trisodium dioxidophosphinecarboxylate oxide
Foscanet sodium
Triapten
Foscarnet sodium
phosphoranecarboxylic acid, dihydroxy-, oxide, trisodium salt
foscarnet sodim
MFCD00013973
trisodium dioxidophosphanecarboxylate oxide
SODIUM FOSCARNET
Phenytion Sodium
Foscavir
trisodium phosphonoformate
FOSCARNET TRISODIUM SALT
phosphonoformate sodium salt

Chemical & Physical Properties

[ Boiling Point ]:
270-272°C

[ Melting Point ]:
62-65 °C(lit.)

[ Molecular Formula ]:
CNa3O5P

[ Molecular Weight ]:
191.951

[ Flash Point ]:
270-272°C

[ Exact Mass ]:
191.917648

[ PSA ]:
113.13000

[ Storage condition ]:
-20℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SY8200000
CHEMICAL NAME :
Phosphinecarboxylic acid, dihydroxy-, oxide, trisodium salt
CAS REGISTRY NUMBER :
63585-09-1
LAST UPDATED :
198910
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C-O5-P.3Na
MOLECULAR WEIGHT :
191.95

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
2400 mg/kg/6D-I
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 2,216,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
384 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4215113

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ Packaging Group ]:
II

[ HS Code ]:
2942000000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • phenyl [ethoxy-(4-methoxyphenoxy)phosphoryl]formate
  • mono-(trimethylsilyl)phosphite
  • Hexamethyldisilazane

DownStream

  • Tris(trimethylsilyl) Phosphite

Customs

[ HS Code ]: 2942000000

Related Compounds

  • Foscarnet Sodium
  • NaBARF
  • Sulfadiazine sodium
  • dexamethasone sodium m-sulfobenzoate
  • (methylsulfanyl)sodium
  • Aminonaphtylsulphonate sodium
  • 2-isopropyl-6-[(4-phenylpiperazino)methyl]-4(3H)-pyrimidinone
  • Lithium 2-chloropyridine-4-sulfinate
  • 1-(3-Methylbutan-2-yl)cyclobutane-1-carbaldehyde
  • 4-(2-(5,6-Dihydroxy-1H-indol-1-yl)vinyl)picolinic acid
  • 2-isopropyl-6-{[4-(3-methylphenyl)piperazino]methyl}-4(3H)-pyrimidinone
  • 4-Methyl-2-(3-methylcyclohexyl)-1,3-oxazole-5-carboxylic acid
  • 5-Ethyl-3',5',6',7'-tetrahydrospiro[cyclopentane-1,4'-imidazo[4,5-c]pyridine]
  • 9-cyclopropyl-N-(pyridin-3-ylmethyl)purin-6-amine
  • 4-Amino-6-(1-methyl-1H-imidazol-5-yl)-2,5-dihydro-1,3,5-triazin-2-one
  • 2',5'-Dimethyl-3,5,6,7-tetrahydrospiro[imidazo[4,5-c]pyridine-4,3'-oxolane]
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