Foscarnet sodium

Modify Date: 2025-08-20 10:26:32

Foscarnet sodium Structure
Foscarnet sodium structure
Common Name Foscarnet sodium
CAS Number 63585-09-1 Molecular Weight 191.951
Density N/A Boiling Point 270-272°C
Molecular Formula CNa3O5P Melting Point 62-65 °C(lit.)
MSDS N/A Flash Point 270-272°C

 Use of Foscarnet sodium


Foscarnet sodium (Trisodium phosphonoformate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet sodium is an antiherpesvirus agent used in cytomegalovirus retinitis[1][2][3].

 Names

Name trisodium phosphonoformate
Synonym More Synonyms

 Foscarnet sodium Biological Activity

Description Foscarnet sodium (Trisodium phosphonoformate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet sodium is an antiherpesvirus agent used in cytomegalovirus retinitis[1][2][3].
Related Catalog
In Vitro Foscarnet sodium (Trisodium phosphonoformate) inhibits Influenza A Victoria (IC50=29 μM), Influenza B HK (IC50=61 μM), and Avian myeloblastosis virus (IC50=5-8 μM),HSV-1, several strains (IC50=0.4-3.5 μM)[2].
References

[1]. Manischewitz JF, et al. Synergistic effect of ganciclovir and foscarnet on cytomegalovirus replication in vitro.Antimicrob Agents Chemother. 1990 Feb;34(2):373-5.

[2]. Oberg B, et al. Antiviral effects of phosphonoformate (PFA, foscarnet sodium).Pharmacol Ther. 1982;19(3):387-415.

[3]. Hakki M, et al. Moving Past Ganciclovir and Foscarnet: Advances in CMV Therapy.Curr Hematol Malig Rep. 2020 Jan 24.

 Chemical & Physical Properties

Boiling Point 270-272°C
Melting Point 62-65 °C(lit.)
Molecular Formula CNa3O5P
Molecular Weight 191.951
Flash Point 270-272°C
Exact Mass 191.917648
PSA 113.13000
Storage condition -20℃

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SY8200000
CHEMICAL NAME :
Phosphinecarboxylic acid, dihydroxy-, oxide, trisodium salt
CAS REGISTRY NUMBER :
63585-09-1
LAST UPDATED :
198910
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C-O5-P.3Na
MOLECULAR WEIGHT :
191.95

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
2400 mg/kg/6D-I
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 2,216,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
384 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4215113

 Safety Information

Hazard Codes Xi
Risk Phrases R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases S26-S36
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
Packaging Group II
HS Code 2942000000

 Synthetic Route

~0%

Foscarnet sodium Structure

Foscarnet sodium

CAS#:63585-09-1

Literature: Noren; Helgstrand; Johansson; Misiorny; Stening Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 264 - 270

~%

Foscarnet sodium Structure

Foscarnet sodium

CAS#:63585-09-1

Literature: Phosphorus, Sulfur and Silicon and the Related Elements, , vol. 51/52, p. 778

 Customs

HS Code 2942000000

 Synonyms

Phosphoranecarboxylic acid, 1,1-dihydroxy-, oxide, sodium salt (1:3)
Trisodium dioxidophosphinecarboxylate oxide
Foscanet sodium
Triapten
Foscarnet sodium
phosphoranecarboxylic acid, dihydroxy-, oxide, trisodium salt
foscarnet sodim
MFCD00013973
trisodium dioxidophosphanecarboxylate oxide
SODIUM FOSCARNET
Phenytion Sodium
Foscavir
trisodium phosphonoformate
FOSCARNET TRISODIUM SALT
phosphonoformate sodium salt
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
Top Suppliers:I want be here




Get all suppliers and price by the below link:

Foscarnet sodium suppliers

Foscarnet sodium price