6-HYDROXYDOPAMINE HYDROBROMIDE

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Names

[ CAS No. ]:
636-00-0

[ Name ]:
6-HYDROXYDOPAMINE HYDROBROMIDE

[Synonym ]:
5-(2-Aminoethyl)-1,2,4-benzenetriol hydrobromide (1:1)
1,2,4-Benzenetriol, 5-(2-aminoethyl)-, hydrobromide (1:1)
5-(2-aminoethyl)benzene-1,2,4-triol,hydrobromide
5-(2-Aminoethyl)benzene-1,2,4-triol hydrobromide (1:1)
EINECS 211-247-0
MFCD00012894
Oxidopamine (hydrobromide)

Chemical & Physical Properties

[ Boiling Point ]:
406ºC at 760 mmHg

[ Melting Point ]:
216-220 °C(lit.)

[ Molecular Formula ]:
C8H12BrNO3

[ Molecular Weight ]:
250.090

[ Flash Point ]:
199.3ºC

[ Exact Mass ]:
249.000046

[ PSA ]:
86.71000

[ LogP ]:
1.96300

[ Appearance of Characters ]:
solid | tan to brown

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DC4600000
CHEMICAL NAME :
1,2,4-Benzenetriol, 5-(2-aminoethyl)-, hydrobromide
CAS REGISTRY NUMBER :
636-00-0
LAST UPDATED :
198910
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C8-H11-N-O3.Br-H
MOLECULAR WEIGHT :
250.12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
100 mg/kg
SEX/DURATION :
female 21-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Paternal Effects - other effects on male Reproductive - Maternal Effects - parturition
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 76,415,1986

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DC4600000

[ HS Code ]:
2922299090

Precursor & DownStream

Precursor

DownStream

  • 1H-Indole-5,6-diol

Customs

[ HS Code ]: 2922299090

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Rho kinase inhibition by fasudil in the striatal 6-hydroxydopamine lesion mouse model of Parkinson disease.

J. Neuropathol. Exp. Neurol. 73(8) , 770-9, (2014)

Chronic degeneration of nigrostriatal projections, followed by nigral dopaminergic cell death, is a key feature of Parkinson disease (PD). This study examines the neuroprotective potential of the rho ...

Curcumin I mediates neuroprotective effect through attenuation of quinoprotein formation, p-p38 MAPK expression, and caspase-3 activation in 6-hydroxydopamine treated SH-SY5Y cells.

Phytother Res. 28(4) , 611-6, (2014)

6-Hydroxydopamine (6-OHDA) selectively enters dopaminergic neurons and undergoes auto-oxidation resulting in the generation of reactive oxygen species and dopamine quinones, subsequently leading to ap...

Ameliorating effects of curcumin on 6-OHDA-induced dopaminergic denervation, glial response, and SOD1 reduction in the striatum of hemiparkinsonian mice.

Eur. Rev. Med. Pharmacol. Sci. 17(10) , 1360-8, (2013)

Inflammation and oxidative stress are believed to contribute to neuronal degeneration of the nigrostriatal dopaminergic (DA) pathway in Parkinson's disease. Curcumin, a component of the yellow curry s...


More Articles

Related Compounds

  • 6-Hydroxydopamine hydrobromide
  • Oxidopamine hydrochloride
  • 4-(2-aminoethyl)-5-hydroxycyclohexa-3,5-diene-1,2-dione
  • 5-Hydroxydopamine
  • 6-Bromomethylisoquinoline hydrobromide
  • 6-Hydroxy-DPAT hydrobromide
  • 6-[4-(7-methyl-7H-purin-6-yl)piperazin-1-yl]-2-(2-methylpropyl)-2,3-dihydropyridazin-3-one
  • Methyl 2-(chloromethyl)-6-oxo-1,6-dihydropyrimidine-5-carboxylate
  • 4-(3-{[2-(propan-2-yl)-1H-imidazol-1-yl]methyl}azetidin-1-yl)benzonitrile
  • 6-(4-{7-Methylthieno[3,2-d]pyrimidin-4-yl}piperazin-1-yl)-2-(propan-2-yl)-2,3-dihydropyridazin-3-one
  • 6-{4-[(3-fluoropyridin-4-yl)methyl]piperazin-1-yl}-7-methyl-7H-purine
  • 2-(2-Methylpropyl)-6-(4-{5-methylpyrazolo[1,5-a]pyrimidin-7-yl}piperazin-1-yl)-2,3-dihydropyridazin-3-one
  • 2-(2-Methylpropyl)-6-(4-{pyrido[2,3-d]pyrimidin-4-yl}piperazin-1-yl)-2,3-dihydropyridazin-3-one
  • 1-(2,3-dihydro-1H-indol-1-yl)-2-{octahydrocyclopenta[c]pyrrol-2-yl}ethan-1-one
  • N-[1-(5-bromo-3-methylpyridin-2-yl)piperidin-4-yl]-5-chloro-N-methylpyrimidin-2-amine
  • 1-{2-cyclopropyl-5H,6H,7H-cyclopenta[d]pyrimidin-4-yl}-4-(4-methyl-1,3-thiazol-2-yl)piperazine
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