Betaxolol

Suppliers

Names

[ CAS No. ]:
63659-18-7

[ Name ]:
Betaxolol

[Synonym ]:
(±)-1-(p-(2-(Cyclopropylmethoxy)ethyl)phenoxy)-3-(isopropylamino)-2-propanol Hydrochloride
1-{4-[2-(cyclopropylmethoxy)ethyl]phenoxy}-3-[(1-methylethyl)amino]propan-2-ol hydrochloride
Betaxolol
MFCD00242958
(+/-)-1-{p-[2-(cyclopropylmethoxy) ethyl] phenoxy}-3-isopropylamino-2-propanol
1-{4-[2-(Cyclopropylmethoxy)ethyl]phenoxy}-3-[(1-methylethyl)amino]propan-2-olhydrochlorid
Betaxololum
2-Propanol, 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-[(1-methylethyl)amino]-, hydrochloride (1:1)
1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol
1-{4-[2-(Cyclopropylmethoxy)ethyl]phenoxy}-3-(isopropylamino)-2-propanol hydrochloride (1:1)
Betaxolol [INN:BAN]
1-{4-[2-(cyclopropylmethoxy)ethyl]phenoxy}-3-(propan-2-ylamino)propan-2-ol hydrochloride (1:1)
Betaxolol hydrochloride
Kerlone
1-{4-[2-(cyclopropylméthoxy)éthyl]phénoxy}-3-[(1-méthyléthyl)amino]propan-2-ol chlorhydrate
Betaxolol (TN)
1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)propan-2-ol
1-{4-[2-(Cyclopropylmethoxy)-ethyl]-phenoxy}-3-isopropylamino-propan-2-ol
1-{4-[2-(Cyclopropylmethoxy)ethyl]phenoxy}-3-(isopropylamino)propan-2-ol hydrochloride (1:1)
Betoptic
Betaxololum [INN-Latin]
Betazolol
2-propanol, 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-[(1-methylethyl)amino]-, hydrochloride
UNII:6X97D2XT0O

Chemical & Physical Properties

[ Density]:
1.067 g/cm3

[ Boiling Point ]:
448ºC at 760 mmHg

[ Melting Point ]:
61-63°C

[ Molecular Formula ]:
C18H29NO3

[ Molecular Weight ]:
307.43

[ Flash Point ]:
224.7ºC

[ PSA ]:
50.72000

[ LogP ]:
2.78430

[ Storage condition ]:
-20°C Freezer

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UA9822500
CHEMICAL NAME :
2-Propanol, 1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-((1-meth ylethyl)amino)-
CAS REGISTRY NUMBER :
63659-18-7
LAST UPDATED :
199506
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C18-H29-N-O3
MOLECULAR WEIGHT :
307.48

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 18(Suppl 7),S1629,1990

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ Safety Phrases ]:
S26

[ WGK Germany ]:
3

[ RTECS ]:
GW2967200

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Diiodomethane
  • isopropylamine
  • 1-[4-(2-Hydroxyethyl)phenoxy]-2,3-epoxypropane
  • 1-benzyloxy-4-(2-cyclopropylmethoxyethyl)benzene
  • 2-(4-(BENZYLOXY)PHENYL)ETHANOL
  • 4-BENZYLOXYPHENYLACETIC ACID ETHYL ESTER
  • 4-[2-(Cyclopropylmethoxy)ethyl]phenol

DownStream

  • LEVOBETAXOLOL
  • Betaxolol hydrochloride

Related Compounds

  • Betaxolol
  • 1-(3,3-Dimethylcyclopentyl)-4-hydroxycyclohexane-1-carboxylic acid
  • 3-(2-Methoxy-6-methylpyridin-4-yl)-2,2-dimethylpropanoic acid
  • 3-Amino-2-(5-fluoropyridin-3-yl)-2-methylpropan-1-ol
  • tert-butyl N-{5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2-oxo-1,2-dihydropyrimidin-4-yl}carbamate
  • Methyl 3-amino-2-(2,2,3,3-tetramethylcyclopropyl)propanoate
  • tert-butyl N-[3-(2-amino-3-hydroxypropyl)-4-fluorophenyl]carbamate
  • 3-amino-2-methyl-2-[6-(1H-1,2,4-triazol-1-yl)pyridin-3-yl]propan-1-ol
  • 2-(2-Methoxy-1,3-thiazol-5-yl)ethane-1-sulfonyl fluoride
  • Methyl 2-amino-3-(2-methoxy-1,3-thiazol-5-yl)-3-methylbutanoate
  • 1-ethyl-3-(hydrazinylmethyl)-1H-pyrazole
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