Val2-Cyclosporine

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Names

[ Name ]:
Val2-Cyclosporine

[Synonym ]:
33-[(4E)-1-Hydroxy-2-methylhex-4-en-1-yl]-6,9,18,24-tetraisobutyl-3,21,30-triisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21,30-tri(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
CyclosporinD
cyclosporine D
Val2-Cyclosporine
1,4,7,10,13,16,19,22,25,28,31-Undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone, 33-[(4E)-1-hydroxy-2-methyl-4-hexen-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-3,21,30-tris(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-
33-[(4E)-1-Hydroxy-2-methyl-4-hexen-1-yl]-6,9,18,24-tetraisobutyl-3,21,30-triisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
7-L-Valinecyclosporin A
Cyclosporin Impurity 4

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
1294.7±65.0 °C at 760 mmHg

[ Melting Point ]:
148-151ºC

[ Molecular Formula ]:
C₆₃H₁₁₃N₁₁O₁₂

[ Molecular Weight ]:
1216.638

[ Flash Point ]:
736.8±34.3 °C

[ Exact Mass ]:
1215.857056

[ PSA ]:
275.64000

[ LogP ]:
3.70

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.468

[ Storage condition ]:
20°C

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H302 + H312 + H332-H319

[ Precautionary Statements ]:
P210-P280-P305 + P351 + P338

[ Hazard Codes ]:
F,Xn,T

[ Risk Phrases ]:
11-20/21/22-36-39/23/24/25-23/24/25

[ Safety Phrases ]:
16-36/37-45-7

[ RIDADR ]:
UN 1648 3 / PGII

[ HS Code ]:
29419090

Articles

Antimalarial activity of cyclosporins A, C and D.

Afr. J. Med. Med. Sci. 23(1) , 47-51, (1994)

Cyclosporin A (CsA) is an immunosuppressive drug widely used in organ transplants. It is also accumulated by the erythrocyte, a site that accommodates one of the stages of malaria parasite. We observe...

Enzymatic synthesis of cyclosporin A.

J. Biol. Chem. 262(36) , 17258-9, (1987)

An enzyme fraction, isolated from crude extracts of the fungus Tolypocladium inflatum, strain 7939/F, is able to synthesize the undecapeptide cyclosporin A. The formation of cyclosporin A was monitore...

In vitro and in vivo comparative studies on immunosuppressive properties of cyclosporines A, C, D and metabolites M1, M17 and M21.

Immunopharmacol. Immunotoxicol. 15(2-3) , 163-77, (1993)

Cyclosporine A (CsA) and its major metabolites: M1, M17 and M21 and two analogues: cyclosporines C (CsC) and D (CsD), were studied for their capacity to interfere with different in vitro activation pa...

Thr2-Cyclosporine
Cyclosporin A
Cyclosporin B
(Val²)-Amyloid β-Protein (1-6) trifluoroacetate salt
Cyclosporin A Acetate
cyclosporine metabolite M17
3-Cyclobutyl-1-methylpyrazol-4-amine;dihydrochloride
1-Methylisoindoline-5-carbonitrile
6-Fluoroisoindoline-1-carboxylic acid
(5-Bromoisoindolin-1-YL)methanol
Benzyl 5-(3-oxomorpholino)-2-(trifluoromethyl)thiazole-4-carboxylate
2-Butoxy-7-[[4-(2-pyrrolidinyl)phenyl]methyl]-5H-pyrrolo[3,2-d]pyrimidin-4-amine
Methyl 6-bromo-4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate
5-Amino-2-(trifluoromethoxy)-3-pyridinecarboxamide
5-Methyl-1-[(oxolan-2-yl)methyl]-1H-pyrazol-3-amine
3'-Amino-4'-(pyridin-4-yl)-[1,1'-biphenyl]-3,5-dicarboxylic acid

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