Val2-Cyclosporine
Val2-Cyclosporine structure
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Common Name | Val2-Cyclosporine | ||
|---|---|---|---|---|
| CAS Number | 63775-96-2 | Molecular Weight | 1216.638 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 1294.7±65.0 °C at 760 mmHg | |
| Molecular Formula | C63H113N11O12 | Melting Point | 148-151ºC | |
| MSDS | N/A | Flash Point | 736.8±34.3 °C | |
| Symbol |
GHS02, GHS07 |
Signal Word | Danger | |
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Antimalarial activity of cyclosporins A, C and D.
Afr. J. Med. Med. Sci. 23(1) , 47-51, (1994) Cyclosporin A (CsA) is an immunosuppressive drug widely used in organ transplants. It is also accumulated by the erythrocyte, a site that accommodates one of the stages of malaria parasite. We observe that CsA and its less potent immunosuppressive analogues C... |
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Enzymatic synthesis of cyclosporin A.
J. Biol. Chem. 262(36) , 17258-9, (1987) An enzyme fraction, isolated from crude extracts of the fungus Tolypocladium inflatum, strain 7939/F, is able to synthesize the undecapeptide cyclosporin A. The formation of cyclosporin A was monitored by incorporation of the radiolabeled constituent amino ac... |
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In vitro and in vivo comparative studies on immunosuppressive properties of cyclosporines A, C, D and metabolites M1, M17 and M21.
Immunopharmacol. Immunotoxicol. 15(2-3) , 163-77, (1993) Cyclosporine A (CsA) and its major metabolites: M1, M17 and M21 and two analogues: cyclosporines C (CsC) and D (CsD), were studied for their capacity to interfere with different in vitro activation pathways. Their inhibition potentials against the reaction of... |
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Does the binding of cyclosporine to calmodulin result in immunosuppression?
Science 234(4772) , 68-71, (1986) The cyclosporines are a family of cyclic endecapeptides that cause a profound suppression of primary immune stimulation both in vitro and in vivo. Recently, the regulatory protein calmodulin (CaM) has been implicated as a target for cyclosporin A (CsA) bindin... |
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The weak immunosuppressant cyclosporine D as well as the immunologically inactive cyclosporine H are potent inhibitors in vivo of phorbol ester TPA-induced biological effects in mouse skin and of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro.
Biochem. Biophys. Res. Commun. 150(2) , 545-51, (1988) Various biological effects induced by the tumor promoting phorbol ester TPA in mouse skin are comparably suppressed by the immunologically inactive cyclosporine H (CsH) and by the strongly immunosuppressive cyclosporine A (CsA). These effects inhibited includ... |
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Synergistic effects of cyclosporin analogs--A, D, G, IMM-125--with rapamycin and/or brequinar.
Transplant. Proc. 26(5) , 3021-4, (1994) Anthocyanins (ACNs) are water-soluble plant pigments that have important functions in plant physiology as well as possible health effects. Over 100 common foods were screened for ACNs, and 24 of them were found to contain ACNs. Concentrations of total ACNs va... |
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Evaluation of a novel semi-automated HPLC procedure for whole blood cyclosporin A confirms equivalence to adjusted monoclonal values from Abbott TDx.
Clin. Chem. Lab Med. 43(2) , 228-36, (2005) The problem in the measurement of cyclosporin (CyA) is that the widely used immuno-based assays suffer from interference by metabolites present in unpredictable excess. To resolve this, the consensus view has been to develop more specific and robust procedure... |
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High-performance liquid chromatographic analysis of cyclosporin G (Nva2-cyclosporine) in human blood.
Ther. Drug Monit. 14(5) , 397-401, (1992) A sensitive high-performance liquid chromatographic method for the analysis of the immunosuppressant cyclosporin G (OG 37-325, Nva2-cyclosporine, CsG) in whole blood has been developed. Sample preparation, employing cyclosporin A (CsA) as internal standard, i... |
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Effect of cyclosporin analogues and FK506 on transcellular transport of daunorubicin and vinblastine via P-glycoprotein.
Pharm. Res. 13(7) , 1073-7, (1996) P-glycoprotein-mediated transcellular transport of anticancer agents and the inhibitory effect of cyclosporin analogs and FK506 were investigated.The transcellular transport of daunorubicin and vinblastine by monolayers of LLC-GA5-COL150 cells which overexpre... |
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[The effects of cyclosporine G and D treatment on experimental autoimmune uveoretinitis and kidney in rats].
Nippon Ganka Gakkai Zasshi 91(10) , 940-50, (1987)
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