Desonide

Suppliers

Names

[ CAS No. ]:
638-94-8

[ Name ]:
Desonide

[Synonym ]:
Prednacinolone
(4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
16a,17a-Isopropylidenedioxyprednisolone
2H-naphth[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, 4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-, (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-
Desowen
2H-Naphth[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, 4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-5-hydroxy-6b-(2-hydroxyacetyl)-4a,6a,8,8-tetramethyl-, (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-
Locapred
Desonide
(4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacétyl)-4a,6a,8,8-tétraméthyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodécahydro-2H-naphto[2',1':4,5]indéno[1,2-d][1,3]dioxol-2-one
Sterax
11b,16a,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione Cyclic 16,17-Acetal with Acetone
16a-Hydroxy-D1-hydrocortisone-16a,17a-acetonide
16a-Hydroxyprednisolone-16a,17-acetonide
Steroderm
16a-Hydroxyprednisolone Acetonide
TRIDESILON
desonidum [INN_la]
MFCD00866151
11β,16α,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone
(4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-Hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-on
(4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-6b-Glycoloyl-5-hydroxy-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
11b,21-Dihydroxy-16a,17-isopropylidenedioxy-1,4-pregnadiene-3,20-dione
Topifug
d-2083
EINECS 211-351-6
11,21-Dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
Budesonide Impurity 6

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
580.1±50.0 °C at 760 mmHg

[ Melting Point ]:
274 - 275ºC

[ Molecular Formula ]:
C24H32O6

[ Molecular Weight ]:
416.507

[ Flash Point ]:
196.9±23.6 °C

[ Exact Mass ]:
416.219879

[ PSA ]:
93.06000

[ LogP ]:
2.62

[ Vapour Pressure ]:
0.0±3.7 mmHg at 25°C

[ Index of Refraction ]:
1.598

[ Storage condition ]:
Refrigerator

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU2800000
CHEMICAL NAME :
Prednisolone-16,17-acetonide, 16-alpha-hydroxy-
CAS REGISTRY NUMBER :
638-94-8
LAST UPDATED :
199203
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C24-H32-O6
MOLECULAR WEIGHT :
416.56
WISWESSER LINE NOTATION :
T F5 E5 B666 GO IO RV AHTTTT&J A1 CQ E1 FV1Q H1 H1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
93 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 20,522,1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3710 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,111,1970

Safety Information

[ Hazard Codes ]:
Xn

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2937210000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 16α-Hydroxyprednisolone

DownStream

  • Budesonide
  • Desisobutyryl-ciclesonide

Customs

[ HS Code ]: 2937210000

Related Compounds

  • Desonide glyoxal
  • Delta14 -Desonide
  • Desonide 1,2-Saturated
  • desonide 21-isobutyrate
  • desonide 21 -isobutyrate
  • Desonide delta 9 (11) analog
  • 7-chloro-4-(cyclopropylmethyl)-4,5-dihydro-1,4-benzoxazepin-3(2H)-one
  • 7-chloro-4-[4-(methylthio)phenyl]-4,5-dihydro-1,4-benzoxazepin-3(2H)-one
  • 1-(2-((3-Methyl-1,2,4-oxadiazol-5-yl)methyl)phenyl)-3-(thiophen-2-yl)urea
  • rel-(1R,2S)-2-Phenyl-1-(phenylmethyl)cyclopropanamine
  • 7-chloro-4-(1,4-dioxan-2-ylmethyl)-4,5-dihydro-1,4-benzoxazepin-3(2H)-one
  • Ethyl 2-(3-bromobenzyl)-4-methylthiazole-5-carboxylate
  • Methyl 3-(2-amino-2-oxoethyl)-5-methylhexanoate
  • 3-(7-bromo-3-oxo-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl)benzonitrile
  • 1-(2-((3-Methyl-1,2,4-oxadiazol-5-yl)methyl)phenyl)-3-phenethylurea
  • 7-bromo-4-(2-fluorophenyl)-4,5-dihydro-1,4-benzoxazepin-3(2H)-one