Tozasertib

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Names

[ CAS No. ]:
639089-54-6

[ Name ]:
Tozasertib

[Synonym ]:
N-[4-({4-(4-Methylpiperazin-1-yl)-6-[(3-methyl-1H-pyrazol-5-yl)amino]pyrimidin-2-yl}sulfanyl)phenyl]cyclopropanecarboxamide
VX-680
MK-0457
Tozasertib Free Base
Cyclopropanecarboxamide, N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]-
Tozasertib
N-[4-({4-(4-Methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl}sulfanyl)phenyl]cyclopropanecarboxamide

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C23H28N8OS

[ Molecular Weight ]:
464.586

[ Exact Mass ]:
464.210663

[ PSA ]:
127.37000

[ LogP ]:
1.18

[ Index of Refraction ]:
1.708

[ Storage condition ]:
-20°C

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • methylpiperazine
  • N-(4-((4-CHLORO-6-((5-METHYL-1H-PYRAZOL-3-YL)AMINO)PYRIMIDIN-2-YL)THIO)PHENYL)CYCLOPROPANECARBOXAMIDE

DownStream

Related Compounds

  • tozasertib
  • Tozasertib
  • Tozasertib lactate
  • 7-benzyl-1,3-dimethyl-8-(2-methylpropylamino)-5H-purin-7-ium-2,6-dione
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 4-Chloro-N-(phenylcarbamoyl)-D-phenylalanine
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • N1-(benzo[d]isothiazol-3-yl)cyclohexane-1,2-diamine hydrochloride
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde