Tozasertib

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Names

[ CAS No. ]:
639089-54-6

[ Name ]:
Tozasertib

[Synonym ]:
N-[4-({4-(4-Methylpiperazin-1-yl)-6-[(3-methyl-1H-pyrazol-5-yl)amino]pyrimidin-2-yl}sulfanyl)phenyl]cyclopropanecarboxamide
VX-680
MK-0457
Tozasertib Free Base
Cyclopropanecarboxamide, N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]-
Tozasertib
N-[4-({4-(4-Methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl}sulfanyl)phenyl]cyclopropanecarboxamide

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C23H28N8OS

[ Molecular Weight ]:
464.586

[ Exact Mass ]:
464.210663

[ PSA ]:
127.37000

[ LogP ]:
1.18

[ Index of Refraction ]:
1.708

[ Storage condition ]:
-20°C

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • methylpiperazine
  • N-(4-((4-CHLORO-6-((5-METHYL-1H-PYRAZOL-3-YL)AMINO)PYRIMIDIN-2-YL)THIO)PHENYL)CYCLOPROPANECARBOXAMIDE

DownStream

Related Compounds

  • tozasertib
  • Tozasertib
  • Tozasertib lactate
  • 4-[(5-Chloro-2-methoxybenzoyl)amino]-3,3-dimethylbutanoic acid
  • 4-[[5-Chloro-2-(methoxymethoxy)benzoyl]amino]-3,3-dimethylbutanoic acid
  • 4-[[4,5-Dichloro-2-(methoxymethoxy)benzoyl]amino]-3,3-dimethylbutanoic acid
  • 4-[[(5-Bromo-2-ethoxy-3-pyridinyl)carbonyl]amino]-3,3-dimethylbutanoic acid
  • 4-[[(5-Chloro-2-ethoxy-3-pyridinyl)carbonyl]amino]-3,3-dimethylbutanoic acid
  • 4-(5-Chloro-2-isopropoxybenzamido)-3,3-dimethylbutanoic acid
  • 4-[(5-Chloro-4-fluoro-2-methoxybenzoyl)amino]-3,3-dimethylbutanoic acid
  • 4-Amino-1,2-dihydro-1,5-dimethyl-2-(6-methyl-2-pyridinyl)-3H-pyrazol-3-one
  • 1,2-Dihydro-1,5-dimethyl-2-(6-methyl-2-pyridinyl)-3H-pyrazol-3-one
  • 4-Amino-1,2-dihydro-2-(4-methoxy-2-pyridinyl)-1,5-dimethyl-3H-pyrazol-3-one
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