Desoxycorticosterone

Names

[ CAS No. ]:
64-85-7

[ Name ]:
Desoxycorticosterone

[Synonym ]:
EINECS 200-596-4
Desoxycorticosterone
(8S,9S,10R,13S,14S,17S)-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
MFCD00003661

Chemical & Physical Properties

[ Density]:
1.15 g/cm3

[ Boiling Point ]:
488ºC at 760 mmHg

[ Melting Point ]:
138-144 °C

[ Molecular Formula ]:
C₂₁H₃₀O₃

[ Molecular Weight ]:
330.46100

[ Flash Point ]:
263.1ºC

[ Exact Mass ]:
330.21900

[ PSA ]:
54.37000

[ LogP ]:
3.69590

[ Index of Refraction ]:
1.559

[ Storage condition ]:
2-8℃

[ Water Solubility ]:
slightly soluble

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HG0350000

CHEMICAL NAME :: 11-Deoxycorticosterone

CAS REGISTRY NUMBER :: 64-85-7

LAST UPDATED :: 199703

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C21-H30-O3

MOLECULAR WEIGHT :: 330.51

WISWESSER LINE NOTATION :: L E5 B666 OV MUTJ A E FV1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 14500 ug/kg

SEX/DURATION :: female 7 day(s) pre-mating female 1-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - delayed effects

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

DOSE :: 8750 ug/kg

SEX/DURATION :: female 7 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Human Liver

DOSE/DURATION :: 2 mmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 370,49,1996

Safety Information

[ Symbol ]:

GHS02, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H301 + H311 + H331-H370

[ Precautionary Statements ]:
P210-P260-P280-P301 + P310-P311

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R40;R48

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
UN 2811 6.1/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
HG0350000

[ HS Code ]:
2942000000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

(8S,9S,10R,13S,14S,17S)-17-(2-bromoacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
(Z)-3-Methoxy-17-(2-oxazolin-4-ylidene)androsta-3,5-diene
(E)-3-Methoxy-17-(2-oxazolin-4-ylidene)androsta-3,5-diene
21-tert-Butyldimethylsilyloxy-3,3:20,20-bis(ethylenedioxy)pregna-5,11-diene
Cortodoxone
21-diazopregn-4-ene-3,20-dione
Pregnenolone
21-bromo-3β-hydroxy-5-pregnen-20-one

DownStream

3alpha,21-dihydroxy-5beta-pregnan-20-one
Corticosterone
11β,18-Epoxy-18,21-dihydroxypregn-4-ene-3,20-dione
18,20-cyclo-20,21-dihydroxy-4-pregnen-3-one
18-hydroxy-11-deoxy Corticosterone
3,20-Dioxopregn-4-en-21-yl 4-bromobenzenesulfonate
Progesterone
Pregnane-3,20-dione,21-hydroxy-, (5b)-
4-Androsten-3-one-5-ene-17-carboxylic acid

Customs

[ HS Code ]: 2942000000

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