PPIase-Parvulin Inhibitor

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Names

[ CAS No. ]:
64005-90-9

[ Name ]:
PPIase-Parvulin Inhibitor

[Synonym ]:
IN1141
diethyl 1,3,6,8-tetrahydro-1,3,6,8-tetraoxobenzo[lmn][3,8]phenanthroline-2,7-diacetate
phenanthroline-(2H,7H)-diacetate
(1,3,6,8-Tetraoxo-1,3,6,8-tetrahydro-benzo[lmn][3,8]phenanthrolin-2,7-diyl)-di-essigsaeure-diaethylester
(1,3,6,8-tetraoxo-1,3,6,8-tetrahydro-benzo[lmn][3,8]phenanthroline-2,7-diyl)-di-acetic acid diethyl ester
phenanthroline-2,7-diacetate
HIC 016C
(1,3,6,8-tetraoxo-1,3,6,8-tetrahydro-benzo[lmn][3,8]phenanthroline-2,7-diyl)-bis-acetic acid diethyl ester

Chemical & Physical Properties

[ Density]:
1.471g/cm3

[ Boiling Point ]:
636.5ºC at 760 mmHg

[ Molecular Formula ]:
C22H18N2O8

[ Molecular Weight ]:
438.38700

[ Flash Point ]:
338.7ºC

[ Exact Mass ]:
438.10600

[ PSA ]:
130.74000

[ LogP ]:
0.19180

[ Index of Refraction ]:
1.641

Safety Information

[ Symbol ]:

GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H400

[ Precautionary Statements ]:
P273

[ RIDADR ]:
UN 3077 9 / PGIII

Synthetic Route

Precursor & DownStream

Precursor

  • 1,4,5,8-Naphthalenetetracarboxylic dianhydride
  • Ethyl glycinate

DownStream

Articles

FIBT versus florbetaben and PiB: a preclinical comparison study with amyloid-PET in transgenic mice.

EJNMMI Res. 5 , 20, (2015)

Over the last decade, an increasing number of studies have been published on the use of amyloid-β (Aβ) PET imaging with different (18)F-radiopharmaceuticals for clinical characterization of Alzheimer'...

Amyloid Beta-Weighted Cortical Thickness: A New Imaging Biomarker in Alzheimer's Disease.

Curr. Alzheimer Res. 12 , 563-71, (2015)

Alzheimer's disease (AD) is the most common neurodegenerative disorder pathologically characterized by amyloid-beta (Aβ) plaques and neurofibrillary tangles. The aggregation of Aβ precedes tau patholo...

Depressive Symptoms and Biomarkers of Alzheimer's Disease in Cognitively Normal Older Adults.

J. Alzheimers Dis. 46 , 63-73, (2015)

Even low levels of depressive symptoms are associated with an increased risk of cognitive decline in older adults without overt cognitive impairment (CN). Our objective was to examine whether very low...


More Articles


Related Compounds

  • PD1-PDL1 inhibitor 1
  • Cathepsin K inhibitor 3
  • Wnt-p53 inhibitor compound 2
  • Multitarget AD inhibitor-1
  • Glycogen Phosphorylase Inhibitor
  • KRAS G12D inhibitor 5
  • 3-benzamido-N-(4-ethylphenyl)benzofuran-2-carboxamide
  • N-(4-ethylphenyl)-3-(naphthalene-1-amido)-1-benzofuran-2-carboxamide
  • N-(4-ethylphenyl)-3-(naphthalene-2-amido)-1-benzofuran-2-carboxamide
  • 3-(2-ethoxynaphthalene-1-amido)-N-(4-ethylphenyl)-1-benzofuran-2-carboxamide
  • 3-(2,2-diphenylacetamido)-N-(4-ethylphenyl)benzofuran-2-carboxamide
  • 3-(3,3-diphenylpropanamido)-N-(4-ethylphenyl)benzofuran-2-carboxamide
  • 3-(5-bromofuran-2-carboxamido)-N-(4-ethylphenyl)benzofuran-2-carboxamide
  • 3-(benzofuran-2-carboxamido)-N-(4-ethylphenyl)benzofuran-2-carboxamide
  • N-(2-((4-ethylphenyl)carbamoyl)benzofuran-3-yl)-9H-xanthene-9-carboxamide
  • N-(2-((4-ethylphenyl)carbamoyl)benzofuran-3-yl)-2-oxo-2H-chromene-3-carboxamide
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