11beta,17alpha-dihydroxy-4-pregnene-3,20-dione

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Names

[ CAS No. ]:
641-77-0

[ Name ]:
11beta,17alpha-dihydroxy-4-pregnene-3,20-dione

[Synonym ]:
21-deoxycortisol
21-Deoxyhydrocortisone
21-Dehydrohydrocortisone
21-DESOXYCORTISOL
21 DEOXYCORTISOL 21-DESOXYCORTISOL
4-pregnene-11-B-17-A-diol-3-20-dione
4-Pregnen-11,17a-diol-3,20-dione-d8
EINECS 211-375-7

Chemical & Physical Properties

[ Density]:
1.21g/cm3

[ Boiling Point ]:
523.9ºC at 760 mmHg

[ Molecular Formula ]:
C₂₁H₃₀O₄

[ Molecular Weight ]:
346.46100

[ Flash Point ]:
284.7ºC

[ Exact Mass ]:
346.21400

[ PSA ]:
74.60000

[ LogP ]:
2.80920

[ Index of Refraction ]:
1.576

[ Storage condition ]:
?20°C

Safety Information

[ Symbol ]:

GHS02, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H301 + H311 + H331-H370

[ Precautionary Statements ]:
P210-P260-P280-P301 + P310-P311

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
F,T

[ Risk Phrases ]:
11-23/24/25-39/23/24/25

[ Safety Phrases ]:
7-16-36/37-45

[ RIDADR ]:
UN1230 - class 3 - PG 2 - Methanol, solution

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

11β,17α-dihydroxy-21-iodopregn-4-ene-3,20-dione
3,3-ethanediyldioxy-4β-chloro-11β,17-dihydroxy-5β-pregnan-20-one
4β-chloro-17-hydroxy-5β-pregnane-3,11,20-trione
1-[(3R,5R,8S,9S,10S,11R,13S,14S,17R)-3,11,17-trihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-yl]ethanone
Pregnane-3,20-dione,11,17-dihydroxy-, (5b,11b)- (9CI)
Pregnane-11,20-dione,3,17-dihydroxy-, (3a,5b)- (9CI)

DownStream

Articles

An LC-MS/MS method for steroid profiling during adrenal venous sampling for investigation of primary aldosteronism.

J. Steroid Biochem. Mol. Biol. 145 , 75-84, (2015)

Steroid profiling for diagnosis of endocrine disorders featuring disordered production of steroid hormones is now possible from advances in liquid chromatography with tandem mass spectrometry (LC-MS/M...

Hirsutism and acne in women: coordinated radioimmunoassays for eight relevant plasma steroids.

Clin. Chem. 40(12) , 2296-305, (1994)

We developed and validated a coordinated set of RIAs for the following eight steroids in single small aliquots (< or = 1 mL) of plasma: androstenedione, dehydroepiandrosterone, 11-deoxycortisol, 21-de...

Superior discriminating value of ACTH-stimulated serum 21-deoxycortisol in identifying heterozygote carriers for 21-hydroxylase deficiency.

Clin. Endocrinol. (Oxf.) 73(6) , 700-6, (2010)

Congenital adrenal hyperplasia caused by classic 21-hydroxylase deficiency (21OHD) is an autosomal recessive disorder with a high prevalence of asymptomatic heterozygote carriers (HTZ) in the general ...

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N-[3-(diethylamino)propyl]-2-ethoxy-4,5-dimethylbenzenesulfonamide
Cyclobutanemethanamine, N-[2-(3-methoxypropoxy)ethyl]
N-[3-(diethylamino)propyl]-2-ethoxy-4-methyl-5-(propan-2-yl)benzene-1-sulfonamide
(1R)-2,2,2-trifluoro-1-(3-fluoropyridin-4-yl)ethan-1-ol
N-[3-(diethylamino)propyl]-2,5-diethoxy-4-methylbenzene-1-sulfonamide
2-Bromo-4-(methoxymethyl)-1,3-thiazole
2-Pyridinyl 2,5-dimethoxy-4-methylbenzenesulfonate
(9H-fluoren-9-yl)methyl N-[4-hydroxy-3-(methylsulfanyl)butan-2-yl]carbamate
2-Pyridinyl 4-chloro-2,5-dimethoxybenzenesulfonate

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