11beta,17alpha-dihydroxy-4-pregnene-3,20-dione

Modify Date: 2024-01-04 16:30:32

11beta,17alpha-dihydroxy-4-pregnene-3,20-dione Structure
11beta,17alpha-dihydroxy-4-pregnene-3,20-dione structure
Common Name 11beta,17alpha-dihydroxy-4-pregnene-3,20-dione
CAS Number 641-77-0 Molecular Weight 346.46100
Density 1.21g/cm3 Boiling Point 523.9ºC at 760 mmHg
Molecular Formula C21H30O4 Melting Point N/A
MSDS Chinese USA Flash Point 284.7ºC
Symbol GHS02 GHS06 GHS08
GHS02, GHS06, GHS08
Signal Word Danger

 Use of 11beta,17alpha-dihydroxy-4-pregnene-3,20-dione


21-Deoxycortisol is an endogenous metabolite. 21-Deoxycortisol is a sign of congenital adrenal hyperplasia[1].

 Names

Name 11beta,17alpha-dihydroxy-4-pregnene-3,20-dione
Synonym More Synonyms

  Biological Activity

Description 21-Deoxycortisol is an endogenous metabolite. 21-Deoxycortisol is a sign of congenital adrenal hyperplasia[1].
Related Catalog
Target

Human Endogenous Metabolite

References

[1]. Franks RC. Plasma 17-hydroxyprogesterone, 21-deoxycortisol and cortisol in congenital adrenal hyperplasia. J Clin Endocrinol Metab. 1974;39(6):1099-1102.

 Chemical & Physical Properties

Density 1.21g/cm3
Boiling Point 523.9ºC at 760 mmHg
Molecular Formula C21H30O4
Molecular Weight 346.46100
Flash Point 284.7ºC
Exact Mass 346.21400
PSA 74.60000
LogP 2.80920
Index of Refraction 1.576
Storage condition ?20°C

 Safety Information

Symbol GHS02 GHS06 GHS08
GHS02, GHS06, GHS08
Signal Word Danger
Hazard Statements H225-H301 + H311 + H331-H370
Precautionary Statements P210-P260-P280-P301 + P310-P311
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes F,T
Risk Phrases 11-23/24/25-39/23/24/25
Safety Phrases 7-16-36/37-45
RIDADR UN1230 - class 3 - PG 2 - Methanol, solution

 Synthetic Route

 Articles28

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Steroid profiling for diagnosis of endocrine disorders featuring disordered production of steroid hormones is now possible from advances in liquid chromatography with tandem mass spectrometry (LC-MS/M...

Hirsutism and acne in women: coordinated radioimmunoassays for eight relevant plasma steroids.

Clin. Chem. 40(12) , 2296-305, (1994)

We developed and validated a coordinated set of RIAs for the following eight steroids in single small aliquots (< or = 1 mL) of plasma: androstenedione, dehydroepiandrosterone, 11-deoxycortisol, 21-de...

Superior discriminating value of ACTH-stimulated serum 21-deoxycortisol in identifying heterozygote carriers for 21-hydroxylase deficiency.

Clin. Endocrinol. (Oxf.) 73(6) , 700-6, (2010)

Congenital adrenal hyperplasia caused by classic 21-hydroxylase deficiency (21OHD) is an autosomal recessive disorder with a high prevalence of asymptomatic heterozygote carriers (HTZ) in the general ...

 Synonyms

21-deoxycortisol
21-Deoxyhydrocortisone
21-Dehydrohydrocortisone
21-DESOXYCORTISOL
21 DEOXYCORTISOL 21-DESOXYCORTISOL
4-pregnene-11-B-17-A-diol-3-20-dione
4-Pregnen-11,17a-diol-3,20-dione-d8
EINECS 211-375-7
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