11beta,17alpha-dihydroxy-4-pregnene-3,20-dione

Modify Date: 2025-08-25 12:09:47

11beta,17alpha-dihydroxy-4-pregnene-3,20-dione Structure
11beta,17alpha-dihydroxy-4-pregnene-3,20-dione structure
 Common Name 11beta,17alpha-dihydroxy-4-pregnene-3,20-dione
CAS Number 641-77-0 Molecular Weight 346.46100
Density 1.21g/cm3 Boiling Point 523.9ºC at 760 mmHg
Molecular Formula C21H30O4 Melting Point N/A
MSDS Chinese USA Flash Point 284.7ºC
Symbol GHS02 GHS06 GHS08
GHS02, GHS06, GHS08		 Signal Word Danger

 Use of 11beta,17alpha-dihydroxy-4-pregnene-3,20-dione


21-Deoxycortisol is an endogenous metabolite. 21-Deoxycortisol is a sign of congenital adrenal hyperplasia[1].

 Names

Name 11beta,17alpha-dihydroxy-4-pregnene-3,20-dione
Synonym More Synonyms

  Biological Activity

Description 21-Deoxycortisol is an endogenous metabolite. 21-Deoxycortisol is a sign of congenital adrenal hyperplasia[1].
Related Catalog
Target

Human Endogenous Metabolite

References

[1]. Franks RC. Plasma 17-hydroxyprogesterone, 21-deoxycortisol and cortisol in congenital adrenal hyperplasia. J Clin Endocrinol Metab. 1974;39(6):1099-1102.

 Chemical & Physical Properties

Density 1.21g/cm3
Boiling Point 523.9ºC at 760 mmHg
Molecular Formula C21H30O4
Molecular Weight 346.46100
Flash Point 284.7ºC
Exact Mass 346.21400
PSA 74.60000
LogP 2.80920
Index of Refraction 1.576
InChIKey LCZBQMKVFQNSJR-UJPCIWJBSA-N
SMILES CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC21C
Storage condition ?20°C

 Safety Information

Symbol GHS02 GHS06 GHS08
GHS02, GHS06, GHS08
Signal Word Danger
Hazard Statements H225-H301 + H311 + H331-H370
Precautionary Statements P210-P260-P280-P301 + P310-P311
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes F,T
Risk Phrases 11-23/24/25-39/23/24/25
Safety Phrases 7-16-36/37-45
RIDADR UN1230 - class 3 - PG 2 - Methanol, solution

 Synthetic Route

 Articles28

More Articles
An LC-MS/MS method for steroid profiling during adrenal venous sampling for investigation of primary aldosteronism.

J. Steroid Biochem. Mol. Biol. 145 , 75-84, (2015)

Steroid profiling for diagnosis of endocrine disorders featuring disordered production of steroid hormones is now possible from advances in liquid chromatography with tandem mass spectrometry (LC-MS/M...

Hirsutism and acne in women: coordinated radioimmunoassays for eight relevant plasma steroids.

Clin. Chem. 40(12) , 2296-305, (1994)

We developed and validated a coordinated set of RIAs for the following eight steroids in single small aliquots (< or = 1 mL) of plasma: androstenedione, dehydroepiandrosterone, 11-deoxycortisol, 21-de...

Superior discriminating value of ACTH-stimulated serum 21-deoxycortisol in identifying heterozygote carriers for 21-hydroxylase deficiency.

Clin. Endocrinol. (Oxf.) 73(6) , 700-6, (2010)

Congenital adrenal hyperplasia caused by classic 21-hydroxylase deficiency (21OHD) is an autosomal recessive disorder with a high prevalence of asymptomatic heterozygote carriers (HTZ) in the general ...

 Bioassay

View more

Name: Primary cell-based high-throughput screening assay for identification of compounds th...
Source: Johns Hopkins Ion Channel Center
Target: regulator of G-protein signaling 4 isoform 2 [Homo sapiens]
External Id: JHICC_RGS_Act_HTS
Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay
Name: High throughput fluorescence intensity-based biochemical assay to screen for small mo...
Source: University of Pittsburgh Molecular Library Screening Center
Target: furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens]
External Id: MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.
Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity
Name: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect...
Source: Broad Institute
Target: N/A
External Id: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity
Name: Flow Cytometric HTS Screen for inhibitors of the ABC transporter ABCB6 for Validation...
Source: NMMLSC
Target: ATP-binding cassette sub-family B member 6, mitochondrial [Homo sapiens]
External Id: UNMCMD_ABCB6_1o_ValidationSet
Name: Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste...
Source: Broad Institute
Target: N/A
External Id: 7124-01_Inhibitor_SinglePoint_HTS_Activity
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 Synonyms

21-deoxycortisol
21-Deoxyhydrocortisone
21-Dehydrohydrocortisone
21-DESOXYCORTISOL
21 DEOXYCORTISOL 21-DESOXYCORTISOL
4-pregnene-11-B-17-A-diol-3-20-dione
4-Pregnen-11,17a-diol-3,20-dione-d8
EINECS 211-375-7
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Chemsrc provides CAS#:641-77-0 MSDS, density, melting point, boiling point, structure, etc. Its name is 11beta,17alpha-dihydroxy-4-pregnene-3,20-dione>> amp version: 11beta,17alpha-dihydroxy-4-pregnene-3,20-dione

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