Oltipraz
Suppliers
Names
[ CAS No. ]:
64224-21-1
[ Name ]:
Oltipraz
[Synonym ]:
Oltipraz
4-methyl-5-pyrazin-2-yldithiole-3-thione
RP-35,972
4-Methyl-5-(pyrazin-2-yl)-3H-1,2-dithiole-3-thione
4-Methyl-5-(2-pyrazinyl)-3H-1,2-dithiole-3-thione
4-Methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione
3H-1,2-DITHIOLE-3-THIONE,4-METHYL-5-PYRAZINYL
4-Methyl-5-pyrazin-2-yl-1,2-dithiole-3-thione
3H-1,2-Dithiole-3-thione, 4-methyl-5-(2-pyrazinyl)-
Chemical & Physical Properties
[ Density]:
1.5±0.1 g/cm3
[ Boiling Point ]:
408.1±55.0 °C at 760 mmHg
[ Melting Point ]:
165-166ºC
[ Molecular Formula ]:
C8H6N2S3
[ Molecular Weight ]:
226.342
[ Flash Point ]:
200.6±31.5 °C
[ Exact Mass ]:
225.969315
[ PSA ]:
114.35000
[ LogP ]:
1.92
[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C
[ Index of Refraction ]:
1.760
[ Storage condition ]:
2-8°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- JP1293000
- CHEMICAL NAME :
- 3H-1,2-Dithiole-3-thione, 4-methyl-5-pyrazinyl-
- CAS REGISTRY NUMBER :
- 64224-21-1
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C8-H6-N2-S3
- MOLECULAR WEIGHT :
- 226.34
- WISWESSER LINE NOTATION :
- T6N DNJ B- ET5SSYJ CUS D1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 43 mg/kg/D
- TOXIC EFFECTS :
- Gastrointestinal - nausea or vomiting
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >50 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- >100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10920 mg/kg/1Y-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 9100 mg/kg/13W-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 21840 mg/kg/1Y-I
- TOXIC EFFECTS :
- Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 1 mg/L
- REFERENCE :
- CBTOE2 Cell Biology and Toxicology. (Princeton Scientific Pub., Inc., 301 N. Harrison St., CN 5279, Princeton, NJ 08540) V.1- 1984- Volume(issue)/page/year: 2,379,1986
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
26-36/37/39
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
JP1293000
[ HS Code ]:
2933990090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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