Quinoline-3-carboxylic acid

Names

[ CAS No. ]:
6480-68-8

[ Name ]:
Quinoline-3-carboxylic acid

[Synonym ]:
EINECS 229-337-3
MFCD00006770
3-Quinolinecarboxylic acid
Quinoline-3-carboxylic acid

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
348.7±17.0 °C at 760 mmHg

[ Melting Point ]:
277-280 °C(lit.)

[ Molecular Formula ]:
C₁₀H₇NO₂

[ Molecular Weight ]:
173.168

[ Flash Point ]:
164.7±20.9 °C

[ Exact Mass ]:
173.047684

[ PSA ]:
50.19000

[ LogP ]:
2.18

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.685

[ Storage condition ]:
Refrigerator

MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S22-S24/25-S37/39-S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

3-Methylquinoline
3-Bromoquinoline
carbon monoxide
D-Phenylglycine ethyl ester hydrochloride
3-(Bromomethyl)quinoline
3-CYANOQUINOLINE
3-Quinolinecarboxaldehyde
Carbon dioxide
Potassium formate
1-(3-Quinolinyl)ethanone

DownStream

Ethyl 3-quinolinecarboxylate
1-Methyl-1,2,3,4-tetrahydroquinoline
methyl quinoline-3-carboxylate
3-Quinolinylmethanol
1,2,3,4-Tetrahydro-3-quinolinecarboxylic acid
3-Quinolinecarboxaldehyde
quinoline-3-carboxamide
methyl 2,4-dicyclopentylquinoline-3-carboxylate
3-Quinolinecarboxylic acid, 1,2,3,4-tetrahydro-, ethyl ester
Quinoline-3-carbonyl chloride

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Effects of norfloxacin on hepatic genes expression of P450 isoforms (CYP1A and CYP3A), GST and P-glycoprotein (P-gp) in Swordtail fish (Xiphophorus Helleri).

Ecotoxicology 24 , 1566-73, (2015)

The presence of antibiotics including norfloxacin in the aquatic environment may cause adverse effects in non-target organisms. But the toxic mechanisms of fluoroquinolone to fish species are still no...

Small-molecule inhibitors of histone acetyltransferase activity: identification and biological properties.

J. Med. Chem. 49 , 6897-907, (2006)

Starting from a yeast phenotypic screening performed on 21 compounds, we described the identification of two small molecules (9 and 18) able to significantly reduce the S. cerevisiae cell growth, thus...

Novel amino-substituted 3-quinolinecarboxylic acid antibacterial agents: synthesis and structure-activity relationships.

J. Med. Chem. 27(9) , 1103-8, (1984)

A series of novel 3-quinolinecarboxylic acid derivatives have been prepared and their antibacterial activity evaluated. These derivatives are characterized by fluorine attached to the 6-position and s...