Orotic acid

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Names

[ CAS No. ]:
65-86-1

[ Name ]:
Orotic acid

[Synonym ]:
Orotonsan
orotic
Oropur
2,6-dihydroxypyrimidine-4-carboxylic acid
Uracil-6-carboxylic acid
Orotic acid
[3H]-Orotic acid
vitamin B13
Oroturic
4-Pyrimidinecarboxylic acid, 1,2,3,6-tetrahydro-2,6-dioxo-
H-ORO-OH
Orotsaure
MFCD00006027
1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidine carboxylic acid
EINECS 200-619-8
2,6-Dioxo-1,2,3,6-tetrahydro-4-pyrimidinecarboxylic acid
1,2,3,6-TETRAHYDRO-2,6-DIOXO-4-PYRIMIDINECARBOXYLIC ACID
2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid
Orotonin
Whey factor
Orotyl
Orodin
6-Carboxyuracil
orodin[qr]
6-uracilic acid
1,2,3,6-Tetrahydro-2,6-dioxopyrimidine-4-carboxylic acid
Animal galactose factor

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
656.9±65.0 °C at 760 mmHg

[ Melting Point ]:
>300°C

[ Molecular Formula ]:
C₅H₄N₂O₄

[ Molecular Weight ]:
156.096

[ Flash Point ]:
351.1±34.3 °C

[ Exact Mass ]:
156.017105

[ PSA ]:
103.02000

[ LogP ]:
-1.40

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.705

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
Slightly soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RM3180000

CHEMICAL NAME :: Orotic acid

CAS REGISTRY NUMBER :: 65-86-1

LAST UPDATED :: 199701

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C5-H4-N2-O4

MOLECULAR WEIGHT :: 156.11

WISWESSER LINE NOTATION :: T6MVMVJ FVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 841 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 770 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Morphological transformation

TYPE OF TEST :: DNA inhibition

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - rat Liver

DOSE/DURATION :: 120 umol/L

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 9,675,1988

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26-S36/37/39-S22

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
RM3180000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

L-Dihydroorotic acid
(cyanomethyl)urea
Glyoxylic acid
2,6-dioxo-3,6-dihydro-2H-1,3-oxazine-4-carboxylic acid
4-Pyrimidinecarboxaldehyde,1,2,3,6-tetrahydro-6-oxo-2-thioxo-
6-(diethoxymethyl)-2-sulfanylidene-1H-pyrimidin-4-one
L-5-carboxymethylhydantoin
4-Pyrimidinecarboxylicacid, 1,2,3,6-tetrahydro-6-oxo-2-thioxo-
6-(Diethoxymethyl)uracil
6-FORMYL-URACIL MONOHYDRATE

DownStream

2,6-Dimethoxy-4-pyrimidinecarboxylic acid
L-Dihydroorotic acid
5-Chloro-2,6-dihydroxy-4-pyrimidinecarboxylic acid
Furo[3,4-d]pyrimidine-2,4,7(3H)-trione,1,5-dihydro-
1,3-Dimethylorotic acid
5,5-Dibromo-2,4,6(1H,3H,5H)-pyrimidinetrione
Orotic acid butyl ester
Uridine monophosphate
Uracil
Citicoline

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