Isosorbide
Suppliers
Names
[ CAS No. ]:
652-67-5
[ Name ]:
Isosorbide
[Synonym ]:
(3R,3aR,6S,6aR)-hexahydrofuro[3,2-b]furane-3,6-diol
Isosorbid
EINECS 211-492-3
D-Glucitol, 1,4:3,6-dianhydro-
D-Isosorbide
dianhydro-D-sorbitol
Isosorbide
dianhydro-D-glucitol
L-Glucitol, 1,4:3,6-dianhydro-
hydronol
1,4:3,6-Dianhydro-D-glucitol
D-1,4:3,6-Dianhydroglucitol
MFCD00064827
at101
1,4:3,6-dianhydrogluticol
IsMotic
(3R,3aR,6S,6aR)-hexahydrofuro[3,2-b]furan-3,6-diol
isobide
1,4:3,6-dianhydro-D-sorbitol
devicoran
1,4:3,6-Dianhydro-L-glucitol
Chemical & Physical Properties
[ Density]:
1.5±0.1 g/cm3
[ Boiling Point ]:
372.1±42.0 °C at 760 mmHg
[ Melting Point ]:
60-63 °C(lit.)
[ Molecular Formula ]:
C6H10O4
[ Molecular Weight ]:
146.141
[ Flash Point ]:
178.8±27.9 °C
[ Exact Mass ]:
146.057907
[ PSA ]:
58.92000
[ LogP ]:
-1.75
[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C
[ Index of Refraction ]:
1.562
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- LZ4380000
- CAS REGISTRY NUMBER :
- 652-67-5
- BEILSTEIN REFERENCE NO. :
- 0080510
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C6-H10-O4
- MOLECULAR WEIGHT :
- 146.16
- WISWESSER LINE NOTATION :
- L44TJ BQ EQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 24150 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,15,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 11 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 64(4),158S,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 289 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,187,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 13600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,71,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 6870 mg/kg
- TOXIC EFFECTS :
- Brain and Coverings - changes in cerebral spinal fluid
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,15,1969
Safety Information
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
R22
[ Safety Phrases ]:
S24/25
[ WGK Germany ]:
2
[ RTECS ]:
LZ4380000
[ HS Code ]:
2932999099
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2932999099
[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%