Isosorbide

Modify Date: 2024-01-02 09:08:13

Isosorbide structure	Common Name	Isosorbide
	CAS Number	652-67-5	Molecular Weight	146.141
	Density	1.5±0.1 g/cm3	Boiling Point	372.1±42.0 °C at 760 mmHg
	Molecular Formula	C₆H₁₀O₄	Melting Point	60-63 °C(lit.)
	MSDS	Chinese	Flash Point	178.8±27.9 °C

Use of Isosorbide

Isosorbide is used as a diuretic used mainly to treat hydrocephalus and is also used to treat glaucoma.

Name	Isosorbide
Synonym	More Synonyms

Description	Isosorbide is used as a diuretic used mainly to treat hydrocephalus and is also used to treat glaucoma.
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Cardiovascular Disease

Density	1.5±0.1 g/cm3
Boiling Point	372.1±42.0 °C at 760 mmHg
Melting Point	60-63 °C(lit.)
Molecular Formula	C₆H₁₀O₄
Molecular Weight	146.141
Flash Point	178.8±27.9 °C
Exact Mass	146.057907
PSA	58.92000
LogP	-1.75
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.562

Isosorbide MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ4380000

CAS REGISTRY NUMBER :: 652-67-5

BEILSTEIN REFERENCE NO. :: 0080510

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C6-H10-O4

MOLECULAR WEIGHT :: 146.16

WISWESSER LINE NOTATION :: L44TJ BQ EQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 24150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,15,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 11 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 64(4),158S,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 289 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,187,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 13600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,71,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6870 mg/kg

TOXIC EFFECTS :: Brain and Coverings - changes in cerebral spinal fluid

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,15,1969

Hazard Codes	Xi
Risk Phrases	R22
Safety Phrases	S24/25
WGK Germany	2
RTECS	LZ4380000
HS Code	2932999099

Precursor 9
CAS#:50-70-4 Sorbitol CAS#:470-15-5 α-L-sorbopyranose CAS#:13042-38-1 (3R,3aR,6S,6aR)... CAS#:7726-97-8 1,4-Anhydro-D-m...
CAS#:492-61-5 β-D-Glucopyranose CAS#:64-19-7 acetic acid CAS#:641-74-7 1,4:3,6-Dianhyd... CAS#:141-78-6 ethyl acetate
CAS#:87-33-2 isosorbide dinitrate
DownStream 10
CAS#:50-70-4 Sorbitol CAS#:13042-39-2 Isosorbide-2-acetate CAS#:65940-93-4 (3R,3aR,6S,6aR)... CAS#:13042-38-1 (3R,3aR,6S,6aR)...
CAS#:185756-31-4 (3R,3AR,6S,6AR)... CAS#:226709-43-9 2,2-DIMETHYL-4-... CAS#:24808-20-6 D-Glucitol,1,4:... CAS#:87-33-2 isosorbide dinitrate
CAS#:641-74-7 1,4:3,6-Dianhyd... CAS#:5306-85-4 1,4:3,6-Dianhyd...

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

(3R,3aR,6S,6aR)-hexahydrofuro[3,2-b]furane-3,6-diol

Isosorbid

EINECS 211-492-3

D-Glucitol, 1,4:3,6-dianhydro-

D-Isosorbide

dianhydro-D-sorbitol

Isosorbide

dianhydro-D-glucitol

L-Glucitol, 1,4:3,6-dianhydro-

hydronol

1,4:3,6-Dianhydro-D-glucitol

D-1,4:3,6-Dianhydroglucitol

MFCD00064827

at101

1,4:3,6-dianhydrogluticol

IsMotic

(3R,3aR,6S,6aR)-hexahydrofuro[3,2-b]furan-3,6-diol

isobide

1,4:3,6-dianhydro-D-sorbitol

devicoran

1,4:3,6-Dianhydro-L-glucitol

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Isosorbide
Price: ￥88.0/25g
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Isosorbide
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Isosorbide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Isosorbide
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Isosorbide
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Isosorbide

Use of Isosorbide

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Isosorbide Biological Activity

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