2-[(2-chloroethyl-nitroso-carbamoyl)amino]acetamide

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Names

[ Name ]:
2-[(2-chloroethyl-nitroso-carbamoyl)amino]acetamide

[Synonym ]:
1-(Carbamoylmethyl)-3-(2-chloroethyl)-3-nitrosourea
Urea,1-(carbamoylmethyl)-3-(2-chloroethyl)-3-nitroso
N-<N'-(2-chloroethyl)-N'-nitrosocarbamoyl>glycinamide
2-(3-(2-chloroethyl))-3-nitrosoureido acetamide
n2-[(2-chloroethyl)(nitroso)carbamoyl]glycinamide

Chemical & Physical Properties

[ Density]:
1.58g/cm3

[ Molecular Formula ]:
C₅H₉ClN₄O₃

[ Molecular Weight ]:
208.60300

[ Exact Mass ]:
208.03600

[ PSA ]:
104.86000

[ LogP ]:
0.49470

[ Index of Refraction ]:
1.597

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YS4552830

CHEMICAL NAME :: Urea, 1-(carbamoylmethyl)-3-(2-chloroethyl)-3-nitroso-

CAS REGISTRY NUMBER :: 65267-04-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C5-H9-Cl-N4-O3

MOLECULAR WEIGHT :: 208.63

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 21230 ug/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 25,829,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 22400 ug/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 25,829,1982

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

H-Gly-NH2.HCl
4-nitrophenyl-N-(2-chloroethyl)carbamate
Glycinamide
CARBAMIC ACID, (2-CHLOROETHYL)NITROSO-, 2,5-DIOXO-1-PYRROLIDINYL ESTER

DownStream

Related Compounds

4-[[[2-(3-Formylphenyl)-5-pyrimidinyl]oxy]methyl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester
4-[[[2-[3-(1-Hydroxyethyl)phenyl]-5-pyrimidinyl]oxy]methyl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester
Streptocyclin
Oxy Cop 8L
2-Fluoro-N-hydroxy-5-methylbenzimidoyl Chloride
6-hydroxy-N-(pyridin-2-yl)pyrimidine-4-carboxamide
5-(2-Nitroethenyl)-1-benzofuran
4-((1E,3E)-4-(5-(Hydroxymethyl)furan-2-yl)buta-1,3-dien-1-yl)benzoic acid
(NE)-N-[1-[2-(2-chloroanilino)-4-methyl-1,3-thiazol-5-yl]ethylidene]hydroxylamine
Methyl 4-bromo-2-(trifluoromethyl)phenylacetate

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