2-[(2-chloroethyl-nitroso-carbamoyl)amino]acetamide

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Names

[ CAS No. ]:
65267-04-1

[ Name ]:
2-[(2-chloroethyl-nitroso-carbamoyl)amino]acetamide

[Synonym ]:
1-(Carbamoylmethyl)-3-(2-chloroethyl)-3-nitrosourea
Urea,1-(carbamoylmethyl)-3-(2-chloroethyl)-3-nitroso
N-<N'-(2-chloroethyl)-N'-nitrosocarbamoyl>glycinamide
2-(3-(2-chloroethyl))-3-nitrosoureido acetamide
n2-[(2-chloroethyl)(nitroso)carbamoyl]glycinamide

Chemical & Physical Properties

[ Density]:
1.58g/cm3

[ Molecular Formula ]:
C5H9ClN4O3

[ Molecular Weight ]:
208.60300

[ Exact Mass ]:
208.03600

[ PSA ]:
104.86000

[ LogP ]:
0.49470

[ Index of Refraction ]:
1.597

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YS4552830
CHEMICAL NAME :
Urea, 1-(carbamoylmethyl)-3-(2-chloroethyl)-3-nitroso-
CAS REGISTRY NUMBER :
65267-04-1
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C5-H9-Cl-N4-O3
MOLECULAR WEIGHT :
208.63

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
21230 ug/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 25,829,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
22400 ug/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 25,829,1982

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • H-Gly-NH2.HCl
  • 4-nitrophenyl-N-(2-chloroethyl)carbamate
  • Glycinamide
  • CARBAMIC ACID, (2-CHLOROETHYL)NITROSO-, 2,5-DIOXO-1-PYRROLIDINYL ESTER

DownStream

Related Compounds

  • tert-butyl (3R)-3-(2-carbamoylphenyl)pyrrolidine-1-carboxylate
  • Tert-butyl 4-(3-fluoro-4-methoxyphenyl)piperazine-1-carboxylate
  • Ethyl 3-[4-hydroxy-3-(neopentyloxysulfonyloxy)phenyl]propanoate
  • 3-(1-(3-Ethyl-3-methylureido)ethyl)phenyl ethyl(methyl)carbamate
  • 2-[1-(2-Fluoro-4-hydroxyphenyl)ethoxy]isoindole-1,3-dione
  • N-[2-(2-bromothiophen-3-yl)ethyl]-2-(3,4-dimethoxyphenyl)acetamide
  • 6-chloro-N-[1-(5-ethylpyridin-2-yl)piperidin-4-yl]pyrimidin-4-amine
  • (E)-4-(4-chloro-6-(4-methoxybenzyloxy)pyrimidin-5-yl)but-3-en-2-one
  • tert-Butyl (2-{[2-(3-bromo-4-cyanophenyl)ethyl]amino}ethyl)carbamate
  • 1-Isopropyl-3-(2-(piperazin-1-YL)ethyl)-1,3-dihydro-2H-benzo[D]imidazol-2-one
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