Metformin
Suppliers
Names
[ CAS No. ]:
657-24-9
[ Name ]:
Metformin
[Synonym ]:
Fluamine
N'-dimethylguanylguanidine
N,N-dimethylimidodicarbonimidic diamide
Diabex
N,N-dimethyl-biguanide
N,N-dimethylbiguanidine
1,1-Dimethylbiguanide
Metiguanide
Metforminum
Glumetza
Dimethylbiguanide
3-(diaminomethylidene)-1,1-dimethylguanidine
EINECS 211-517-8
Diabetosan
Glucophage
Chemical & Physical Properties
[ Density]:
1.0743
[ Boiling Point ]:
229.23°C
[ Melting Point ]:
199-200 °C
[ Molecular Formula ]:
C4H11N5
[ Molecular Weight ]:
129.164
[ Flash Point ]:
58.1±22.6 °C
[ Exact Mass ]:
129.101440
[ PSA ]:
88.99000
[ LogP ]:
-2.31
[ Appearance of Characters ]:
Solid,White to Light Brown
[ Vapour Pressure ]:
1.3±0.3 mmHg at 25°C
[ Index of Refraction ]:
1.576
[ Water Solubility ]:
Acetonitrile (Slightly), Aqueous Acid (Slightly), Dichloromethane (Slightly), DM
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DU1790000
- CHEMICAL NAME :
- Biguanide, 1,1-dimethyl-
- CAS REGISTRY NUMBER :
- 657-24-9
- LAST UPDATED :
- 199601
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C4-H11-N5
- MOLECULAR WEIGHT :
- 129.20
- WISWESSER LINE NOTATION :
- MUYZMYUM&N1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 230 mg/kg
- TOXIC EFFECTS :
- Behavioral - hallucinations, distorted perceptions Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 247 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 146 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Amphibian - frog
- DOSE/DURATION :
- 5 gm/kg
- TOXIC EFFECTS :
- Behavioral - hallucinations, distorted perceptions Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 6 gm/kg
- SEX/DURATION :
- female 1-12 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death
MUTATION DATA
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 2 gm/L/48H
- REFERENCE :
- GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981 *** REVIEWS *** TOXICOLOGY REVIEW CLPTAT Clinical Pharmacology and Therapeutics (St. Louis). (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1960- Volume(issue)/page/year: 5,480,1964 TOXICOLOGY REVIEW ADVPA3 Advances in Pharmacology. (New York, NY) V.1-6, 1962-68. For publisher information, see AVPCAQ. Volume(issue)/page/year: 4,263,1966