1,10-Phenanthroline

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Names

[ CAS No. ]:
66-71-7

[ Name ]:
1,10-Phenanthroline

[Synonym ]:
1,10-Phenanthroline
4,5-Diazaphenanthrene
4,5-Phenanthroline
ORTHOPHENANTHROLINE
EINECS 200-629-2
1,10-o-Phenanthroline
o-Phenanthroline
β-Phenanthroline
1,10-Fenanthroline
phenanthroline
MFCD00011678
1,10-Fenanthrolin
phen
10-Phenanthroline
T B666 CN NNJ

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
365.1±15.0 °C at 760 mmHg

[ Melting Point ]:
114-117 °C(lit.)

[ Molecular Formula ]:
C12H8N2

[ Molecular Weight ]:
180.205

[ Flash Point ]:
164.8±11.7 °C

[ Exact Mass ]:
180.068741

[ PSA ]:
25.78000

[ LogP ]:
1.78

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.740

[ Storage condition ]:
Refrigerator

[ Stability ]:
Stable. Hygroscopic. Store under nitrogen. Incompatible with strong acids, strong oxidizing agents.

[ Water Solubility ]:
slightly soluble

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SF8300000
CHEMICAL NAME :
1,10-Phenanthroline
CAS REGISTRY NUMBER :
66-71-7
LAST UPDATED :
199701
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C12-H8-N2
MOLECULAR WEIGHT :
180.22
WISWESSER LINE NOTATION :
T B666 CN NNJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
75 mg/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition Kidney, Ureter, Bladder - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
18 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
30 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Human Leukocyte
DOSE/DURATION :
5 mg/L
REFERENCE :
ONCOBS Oncology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.21- 1967- Volume(issue)/page/year: 46,193,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82276 No. of Facilities: 1002 (estimated) No. of Industries: 12 No. of Occupations: 11 No. of Employees: 8324 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82276 No. of Facilities: 2265 (estimated) No. of Industries: 33 No. of Occupations: 35 No. of Employees: 40330 (estimated) No. of Female Employees: 2577 (estimated)

Safety Information

[ Symbol ]:

GHS06, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H410

[ Precautionary Statements ]:
P273-P301 + P310-P501

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic

[ Risk Phrases ]:
R25;R50/53

[ Safety Phrases ]:
S45-S60-S61

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
SF8437000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
29339990

Synthetic Route

Precursor & DownStream

Precursor

  • Disodium succinate
  • 1,2,3,4-tetrahydro-1,10-phenanthroline
  • 5,6-Epoxy-1,10-phenanthroline
  • Tetramethyltin
  • triacetylmethane
  • 8-Amino-7-quinolinecarbaldehyde
  • (8R,9S,10R,13S,14S,17S)-3-butoxy-10,13,17-trimethyl-1,2,7,8,9,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-ol

DownStream

  • 2-phenyl-1,10-phenanthroline
  • 2-Cyano-1,10-phenanthroline
  • 6-Fluoro-2-methyl-1H-indole
  • 4-Di-p-tolylamino-benzaldehyde
  • 1,10-Phenanthrolin-5-amine
  • 5-Bromo-1,10-phenanthroline
  • FERROCYPHEN
  • iron(2+),oxalate,1,10-phenanthroline
  • 2-(4-methoxyphenyl)-1,10-phenanthroline
  • 2-(4-methoxyphenyl)-9-[6-[9-(4-methoxyphenyl)-1,10-phenanthrolin-2-yl]hexyl]-1,10-phenanthroline

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Related Compounds

  • 1,10-phenanthroline
  • 1,10-PHENANTHROLINE HCL
  • zinc,1,10-phenanthroline
  • 2-Me-1,10-phenanthroline
  • CuCl*1,10-phenanthroline
  • zinc,1,10-phenanthroline
  • 2,3-Dihydrofuro[3,4-b][1,4]dioxine
  • Cyclopentaneacetic acid, 1-[2-oxo-2-[[4-(2-phenyldiazenyl)phenyl]amino]ethyl]-
  • Carbamic acid, N-[4-[(1E)-2-phenyldiazenyl]phenyl]-, 2-methylpropyl ester
  • Propanamide, 2-chloro-N-[4-(2-phenyldiazenyl)phenyl]-
  • [(3S,4S,5R)-4,5-diacetyloxy-6-(4-ethylphenoxy)-2-(iodomethyl)oxan-3-yl] acetate
  • Pentanoic acid, 5-[[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl]amino]-5-oxo-
  • Cyclopentaneacetic acid, 1-[2-[[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl]amino]-2-oxoethyl]-
  • 3-Cyclohexene-1-carboxylic acid, 6-[[[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl]amino]carbonyl]-
  • Benzoic acid, 2-[[[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl]amino]carbonyl]-
  • Acetamide, 2-chloro-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl]-
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