alpha-Cyano-1-piperidineacrylic acid ethyl ester

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Names

[ CAS No. ]:
6630-63-3

[ Name ]:
alpha-Cyano-1-piperidineacrylic acid ethyl ester

[Synonym ]:
Piperidinomethylen-cyanessigsaeureaethylester
2-cyano-3-piperidin-1-yl-acrylic acid ethyl ester
1H-Pyrrole-2-carbonitrile,3-phenyl
2-Cyano-3-phenyl-pyrrol
3-Piperidino-2-cyan-acrylsaeureaethylester
3-phenyl-pyrrole-2-carbonitrile

Chemical & Physical Properties

[ Density]:
1.159g/cm3

[ Boiling Point ]:
317.8ºC at 760 mmHg

[ Molecular Formula ]:
C11H16N2O2

[ Molecular Weight ]:
208.25700

[ Flash Point ]:
146ºC

[ Exact Mass ]:
208.12100

[ PSA ]:
53.33000

[ LogP ]:
1.38078

[ Index of Refraction ]:
1.556

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TM4021000
CHEMICAL NAME :
1-Piperidineacrylic acid, alpha-cyano-, ethyl ester
CAS REGISTRY NUMBER :
6630-63-3
LAST UPDATED :
198909
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C11-H16-N2-O2
MOLECULAR WEIGHT :
208.29
WISWESSER LINE NOTATION :
T6NTJ A1UYCN&VO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 7,68,1964

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Piperidine
  • Triethyl orthoformate
  • Ethyl cyanoacetate

DownStream

Related Compounds

  • 3-cyano-1-ethoxycarbonylmethyl-pyrrole-2-carboxylic acid ethyl ester
  • 3-cyano-1,3-dimethyl-2-oxo-cyclopentanecarboxylic acid ethyl ester
  • 1-cyano-1-ethoxycarbonyl-1-cyclooctylmethane
  • 1-cyano-1-ethoxycarbonyl-1-propene
  • 3'-cyanobiphenyl-4-carboxylic acid ethyl ester
  • (1-cyano-1,2,3,4-tetrahydronaphthalen-1-yl)-acetic acid ethyl ester
  • 4-(Thiolan-2-yl)-1,3-thiazol-2-amine
  • 1-(difluoromethyl)-6-methyl-1H-indole
  • 6,8-Dichloro-2-(3,4-dimethoxyphenyl)imidazo[1,2-a]pyridine
  • 2-Fluoro-4-methanesulfonylbutan-1-amine
  • 1-(6-methoxy-1H-indol-2-yl)-2-methylpropan-2-ol
  • 2-Fluoro-2-(quinolin-7-yl)ethan-1-amine
  • 2-(6-methoxy-1H-indol-2-yl)-2-methylpropanoic acid
  • 1-[2-(Aminooxy)ethyl]naphthalen-2-ol
  • 2-(5-Bromo-2-fluorophenyl)-2-fluoroethan-1-amine
  • 2-fluoro-2-(1-methyl-1H-imidazol-2-yl)ethan-1-amine
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