Benzenesulfonamide,N-[(cyclohexylamino)carbonyl]-4-methyl-
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Names
[ CAS No. ]:
664-95-9
[ Name ]:
Benzenesulfonamide,N-[(cyclohexylamino)carbonyl]-4-methyl-
[Synonym ]:
Glicosil
TOLCYCLAMIDE
Gliciclamide
1-cyclohexyl-3-tosylurea
Cyclamide
Glycyclamid
N-cyclohexyl-N'-(toluene-4-sulfonyl)-urea
Agliral
Cyclamid
N-Cyclohexyl-N'-(toluol-4-sulfonyl)-harnstoff
Cychloral
N1-p-Toluolsulfonyl-N2-cyclohexylharnstoff
Glycyclamide
Tolhexamide
N-(cyclohexylcarbamoyl)-4-methylbenzenesulfonamide
Chemical & Physical Properties
[ Density]:
1.26g/cm3
[ Molecular Formula ]:
C14H20N2O3S
[ Molecular Weight ]:
296.39
[ Exact Mass ]:
296.11900
[ PSA ]:
83.65000
[ LogP ]:
4.17820
[ Index of Refraction ]:
1.578
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- YS7800000
- CHEMICAL NAME :
- Urea, 1-cyclohexyl-3-(p-tolylsulfonyl)-
- CAS REGISTRY NUMBER :
- 664-95-9
- BEILSTEIN REFERENCE NO. :
- 1995860
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C14-H20-N2-O3-S
- MOLECULAR WEIGHT :
- 296.42
- WISWESSER LINE NOTATION :
- L6TJ AMVMSWR D1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 870 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 12,268,1957
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1150 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,280,1970 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 800 mg/kg
- SEX/DURATION :
- female 9 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death
- REFERENCE :
- FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 28,616,1965