Benzenesulfonamide,N-[(cyclohexylamino)carbonyl]-4-methyl-

Modify Date: 2025-08-26 18:03:35

Benzenesulfonamide,N-[(cyclohexylamino)carbonyl]-4-methyl- structure	Common Name	Benzenesulfonamide,N-[(cyclohexylamino)carbonyl]-4-methyl-
	CAS Number	664-95-9	Molecular Weight	296.39
	Density	1.26g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₄H₂₀N₂O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Benzenesulfonamide,N-[(cyclohexylamino)carbonyl]-4-methyl-

Cyclamide (Cicloral), an oligopeptide, can be produced by cyanobacteria algae strains. Cyclamide can be used for the research of diabetes mellitus[1][2].

Name	1-cyclohexyl-3-(4-methylphenyl)sulfonylurea
Synonym	More Synonyms

Description	Cyclamide (Cicloral), an oligopeptide, can be produced by cyanobacteria algae strains. Cyclamide can be used for the research of diabetes mellitus[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
References	[1]. GRINCHENKO TS, et, al. CYCLAMIDE (K-386) TREATMENT OF DIABETES MELLITUS. Fed Proc Transl Suppl. Jul-Aug 1964;23:767-8. [2]. Natumi R, et, al. Cyanobacterial Toxins and Cyanopeptide Transformation Kinetics by Singlet Oxygen and pH-Dependence in Sunlit Surface Waters. Environ Sci Technol. 2021 Nov 16;55(22):15196-15205.

Description

Cyclamide (Cicloral), an oligopeptide, can be produced by cyanobacteria algae strains. Cyclamide can be used for the research of diabetes mellitus[1][2].

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

References

[1]. GRINCHENKO TS, et, al. CYCLAMIDE (K-386) TREATMENT OF DIABETES MELLITUS. Fed Proc Transl Suppl. Jul-Aug 1964;23:767-8.

[2]. Natumi R, et, al. Cyanobacterial Toxins and Cyanopeptide Transformation Kinetics by Singlet Oxygen and pH-Dependence in Sunlit Surface Waters. Environ Sci Technol. 2021 Nov 16;55(22):15196-15205.

Density	1.26g/cm3
Molecular Formula	C₁₄H₂₀N₂O₃S
Molecular Weight	296.39
Exact Mass	296.11900
PSA	83.65000
LogP	4.17820
Index of Refraction	1.578

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YS7800000

CHEMICAL NAME :: Urea, 1-cyclohexyl-3-(p-tolylsulfonyl)-

CAS REGISTRY NUMBER :: 664-95-9

BEILSTEIN REFERENCE NO. :: 1995860

LAST UPDATED :: 199706

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C14-H20-N2-O3-S

MOLECULAR WEIGHT :: 296.42

WISWESSER LINE NOTATION :: L6TJ AMVMSWR D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 870 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 12,268,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,280,1970 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 800 mg/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 28,616,1965

4-Toluenesulfonamide

CAS#:70-55-3

cyclohexylisocyanate

CAS#:3173-53-3

~95%

Benzenesulfonam...

CAS#:664-95-9

Literature: Cervello; Sastre Synthesis, 1990 , # 3 p. 221 - 222

p-Toluenesulfon...

CAS#:4083-64-1

Cyclohexylamine

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~33%

Benzenesulfonam...

CAS#:664-95-9

Literature: Howbert; Grossman; Crowell; Rieder; Harper; Kramer; Tao; Aikins; Poore; Rinzel; Grindey; Shaw; Todd Journal of Medicinal Chemistry, 1990 , vol. 33, # 9 p. 2393 - 2407

Ethyl [(4-methy...

CAS#:5577-13-9

Cyclohexylamine

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~75%

Benzenesulfonam...

CAS#:664-95-9

Literature: Xi, Pin-xian; Xu, Zhi-hong; Liu, Xiao-hui; Cheng, Feng-juan; Zeng, Zheng-zhi Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2008 , vol. 71, # 2 p. 523 - 528 Title/Abstract Full Text View citing articles Show Details Xi, Pin-Xian; Xu, Zhi-Hong; Liu, Xiao-Hui; Chen, Feng-Juan; Huang, Liang; Zeng, Zheng-Zhi Chemical and Pharmaceutical Bulletin, 2008 , vol. 56, # 4 p. 541 - 546

Tosyl chloride

CAS#:98-59-9

Benzenesulfonam...

CAS#:664-95-9

Literature: Yuriev, Elizabeth; Kong, David C.M.; Iskander, Magdy N. European Journal of Medicinal Chemistry, 2004 , vol. 39, # 10 p. 835 - 847

Formamide,N-cyc...

CAS#:766-93-8

p-Toluenesulfon...

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Benzenesulfonam...

CAS#:664-95-9

Literature: Logemann; Artini Chemische Berichte, 1957 , vol. 90, p. 2527,2531

(N-cyclohexyl-f...

CAS#:109840-62-2

Benzenesulfonam...

CAS#:664-95-9

Literature: Logemann; Artini Chemische Berichte, 1957 , vol. 90, p. 2527,2531

Hydrochloric acid

CAS#:7647-01-0

(N-cyclohexyl-f...

CAS#:109840-62-2

Benzenesulfonam...

CAS#:664-95-9

Literature: Logemann; Artini Chemische Berichte, 1957 , vol. 90, p. 2527,2531

Precursor 9
CAS#:70-55-3 4-Toluenesulfonamide CAS#:3173-53-3 cyclohexylisocyanate CAS#:4083-64-1 p-Toluenesulfon... CAS#:108-91-8 Cyclohexylamine
CAS#:5577-13-9 Ethyl [(4-methy... CAS#:98-59-9 Tosyl chloride CAS#:766-93-8 Formamide,N-cyc... CAS#:109840-62-2 (N-cyclohexyl-f...
CAS#:7647-01-0 Hydrochloric acid
DownStream 0

Glicosil

TOLCYCLAMIDE

Gliciclamide

1-cyclohexyl-3-tosylurea

Cyclamide

Glycyclamid

N-cyclohexyl-N'-(toluene-4-sulfonyl)-urea

Agliral

Cyclamid

N-Cyclohexyl-N'-(toluol-4-sulfonyl)-harnstoff

Cychloral

N1-p-Toluolsulfonyl-N2-cyclohexylharnstoff

Glycyclamide

Tolhexamide

N-(cyclohexylcarbamoyl)-4-methylbenzenesulfonamide

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Use of Benzenesulfonamide,N-[(cyclohexylamino)carbonyl]-4-methyl-

Names

Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Synthetic Route

Precursor & DownStream

Synonyms

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