Ansamitocin P-3

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Names

[ CAS No. ]:
66547-09-9

[ Name ]:
Ansamitocin P-3

[Synonym ]:
maytansinol 3-butyrate
Propanoic acid, 2-methyl-, (1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1.0]hexacosa-10,12,1
 4(26),16,18-pentaen-6-yl ester
C32H43ClN2O9
Maytansinol butyrate
(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-Chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1.0]hexacosa-10(26),11,13,16,18-pentaen-6-yl 2- methylpropanoate
Ansamitocin P-3
MFCD00274586
Ansamitocin P 3'

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
833.1±65.0 °C at 760 mmHg

[ Melting Point ]:
182-185℃

[ Molecular Formula ]:
C32H43ClN2O9

[ Molecular Weight ]:
635.145

[ Flash Point ]:
457.7±34.3 °C

[ Exact Mass ]:
634.265686

[ PSA ]:
136.16000

[ LogP ]:
5.09

[ Vapour Pressure ]:
0.0±3.2 mmHg at 25°C

[ Index of Refraction ]:
1.583

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OQ2293000
CHEMICAL NAME :
Maytansine, 3-de(2-(acetylmethylamino)propionyloxy)-3-hydroxy-, butyrate (ester)
CAS REGISTRY NUMBER :
66547-09-9
LAST UPDATED :
199401
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C32-H43-Cl-N2-O9
MOLECULAR WEIGHT :
635.22

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
625 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #78-130495

Safety Information

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R20/22;R36/37/38

[ Safety Phrases ]:
S26;S36

[ WGK Germany ]:
3

[ RTECS ]:
OQ2293000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Maytansinol
  • Butyric Acid

DownStream

Related Compounds

  • ANSAMITOCIN P-3
  • ANSAMITOCIN P-4
  • 2-[p-[3-(2-chloroethyl)ureido]phenyl]-N-methylsuccinimide
  • 1-[[p-(3-Morpholino-1-propynyl)phenyl]ethynyl]-1-cyclohexanol
  • 1-[p-[3-(Dimethylamino)propyl]phenethyl]-1-cyclohexanol
  • 1-[[p-(3-Piperidino-1-propynyl)phenyl]ethynyl]cyclohexanol
  • 5-cyclopropyl-N-(2-morpholino-2-(thiophen-3-yl)ethyl)isoxazole-3-carboxamide
  • tert-Butyl 2-(((pyridin-3-ylmethyl)sulfonyl)methyl)piperidine-1-carboxylate
  • 3-(4-fluorophenyl)-1-methyl-N-(2-morpholino-2-(thiophen-3-yl)ethyl)-1H-pyrazole-5-carboxamide
  • (E)-N-(2-morpholino-2-(thiophen-3-yl)ethyl)-2-(p-tolyl)ethenesulfonamide
  • N-(2-morpholino-2-(thiophen-3-yl)ethyl)-4-oxo-2,4,5,6-tetrahydro-1H-pyrrolo[3,2,1-ij]quinoline-8-sulfonamide
  • (3-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)(2-phenylmorpholino)methanone
  • (3-(2,5-dimethoxyphenyl)-1-methyl-1H-pyrazol-5-yl)(2-phenylmorpholino)methanone
  • 4-((3,5-Difluorobenzyl)sulfonyl)-2-phenylmorpholine
  • 2-(4-((2-Phenylmorpholino)sulfonyl)phenyl)-1,2-thiazinane 1,1-dioxide
  • N-(adamantan-1-yl)-2-phenylmorpholine-4-carboxamide
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