ETHYLPHENACETIN

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Names

[ CAS No. ]:
66922-67-6

[ Name ]:
ETHYLPHENACETIN

[Synonym ]:
Ethylphenacetin
p-ACETOPHENETIDIDE,N-ETHYL
N-Aethyl-phenacetin

Chemical & Physical Properties

[ Density]:
1.046g/cm3

[ Boiling Point ]:
324.3ºC at 760 mmHg

[ Molecular Formula ]:
C₁₂H₁₇NO₂

[ Molecular Weight ]:
207.26900

[ Flash Point ]:
149.9ºC

[ Exact Mass ]:
207.12600

[ PSA ]:
29.54000

[ LogP ]:
2.45810

[ Index of Refraction ]:
1.529

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AM4400000

CHEMICAL NAME :: p-Acetophenetidide, N-ethyl-

CAS REGISTRY NUMBER :: 66922-67-6

BEILSTEIN REFERENCE NO. :: 3274909

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C12-H17-N-O2

MOLECULAR WEIGHT :: 207.30

WISWESSER LINE NOTATION :: 2OR DN2&V1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - acute pulmonary edema Blood - other changes

REFERENCE :: AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC. Volume(issue)/page/year: 33,216,1894

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2700 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Cardiac - other changes

REFERENCE :: AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC. Volume(issue)/page/year: 33,216,1894

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Cardiac - pulse rate Cardiac - other changes

REFERENCE :: AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC. Volume(issue)/page/year: 33,216,1894

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Ethanoic anhydride
Diethyl sulfate
Phenacetin
4-Acetamidophenol
2-Phenoxyethanamine
Ethyl iodide
Bromoethane

DownStream

Related Compounds

10-Hydroxy-2,2-dimethyl-3,4-dihydropyrano[3,2-g]chromen-8-one
Tetramethyl-[1,4]dioxane-2,6-dione
N-(2-tert-butyl-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-benzo[d]imidazol-5-yl)benzenesulfonamide
Carbamodithioic acid, [(1S,2R)-2-hydroxy-1-methyl-2-phenylethyl]methyl-
2-[4-(1H-benzimidazol-2-yl)-1-piperidinyl]-2-oxoethyl 2-isopropyl-5-methylphenyl ether
Benzyl 2-(bromomethyl)acrylate
Methyl 2-{[(tert-butoxy)carbonyl]amino}-3-hydroxy-3-(2-nitrophenyl)propanoate
N-[4-(Aminomethyl)phenyl]-1-propanesulfonamide
Ethyl 2-ethoxy-3-[4-(2-bromoethoxy)-phenyl]propanoate
Ethyl 5,8-dihydro-2-(methylthio)-5-oxo-8-(thiazol-2-yl)pyrido[2,3-d]pyrimidine-6-carboxylate

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