DL-Mevalonolactone

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Names

[ CAS No. ]:
674-26-0

[ Name ]:
DL-Mevalonolactone

[Synonym ]:
(3RS)-mevalonolactone
MEVALONIC LACTONE
(+/-)-MEVALONOLACTONE
EINECS 211-615-0
DL-MEVALOLACTONE
MFCD00006648
DL-mevalonic acid lactone
D,L-MEVELONIC ACID LACTONE
MEVALONIC ACID LACTONE,DL
(RS)-mevalonolactone
(S/R)-mevalonolactone

Chemical & Physical Properties

[ Density]:
1.189 g/cm3

[ Boiling Point ]:
145-150 °C5 mm Hg(lit.)

[ Melting Point ]:
28 °C(lit.)

[ Molecular Formula ]:
C6H10O3

[ Molecular Weight ]:
130.14200

[ Flash Point ]:
>230 °F

[ Exact Mass ]:
130.06300

[ PSA ]:
46.53000

[ LogP ]:
0.07440

[ Index of Refraction ]:
n20/D 1.473(lit.)

[ Storage condition ]:
2-8°C

[ Stability ]:
Hygroscopic

MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2932999099

Synthetic Route

Precursor & DownStream

Precursor

  • 3-Methylpentane-1,3,5-triol
  • 5-[(4-nitrophenyl)methylcarbamoyloxy]-3-hydroxy-3-methylpentanoic acid
  • 4-Hydroxy-4-methyldihydro-2H-pyran-2,6(3H)-dione
  • (R/S)-3-methyl-5-hexene-1,3-diol
  • (4-nitrophenyl)methylcarbamic acid 3-hydroxy-3-methyl-5-oxopentyl ester
  • 3-hydroxy-3-methylhex-5-en-1-yl methyl(4-nitrophenyl)carbamate
  • 4-methyloxane-2,4-diol
  • Trimethylsilyl acetate

DownStream

  • 3-hydroxy-3-methylglutaric acid
  • D-Mevalonolactone
  • 3-Methylpentane-1,3,5-triol
  • 3-Hydroxy-3-methylvaleric Acid
  • (4S)-4-hydroxy-4-methyloxan-2-one
  • Dehydromevalonolactone
  • Ergosta-2,24-dien-26-oicacid, 5,6-epoxy-22,27-dihydroxy-1-oxo-, d-lactone, (5b,6b,22R)- (9CI)
  • Withaferin A

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

In vitro and in vivo anticancer effects of mevalonate pathway modulation on human cancer cells.

Br. J. Cancer 111(8) , 1562-71, (2014)

The increasing usage of statins (the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors) has revealed a number of unexpected beneficial effects, including a reduction in cancer risk.We investi...

Synthesis and HMG-CoA reductase inhibition of 2-cyclopropyl-4-thiophenyl-quinoline mevalonolactones.

Bioorg. Med. Chem. 17(23) , 7915-23, (2009)

A novel series of 2-cyclopropyl-4-thiophenyl quinoline-based mevalonolactones were synthesized from the substituted anilines by several reactions. Among them, (4R,6S)-6-[(E)-2-(2-cyclopropyl-6-fluoro-...

Highly sensitive assay of HMG-CoA reductase activity by LC-ESI-MS/MS.

J. Lipid Res. 48(5) , 1212-20, (2007)

We have developed a new sensitive and specific nonradioisotope assay method to measure the activity of HMG-CoA reductase, the rate-controlling enzyme in the cholesterol biosynthetic pathway. This meth...


More Articles


Related Compounds

  • DL-Mevalonolactone-d7
  • DL-Mevalonolactone-d3
  • dl-mevalonolactone-4,4,5,5-d4
  • dl-4-hydroxy-3-methoxymandelic acid
  • DL-3-PYRROLIDINOL
  • DL-Aspartic acid-d3