DL-Mevalonolactone

Modify Date: 2025-08-22 10:16:24

DL-Mevalonolactone structure	Common Name	DL-Mevalonolactone
	CAS Number	674-26-0	Molecular Weight	130.14200
	Density	1.189 g/cm3	Boiling Point	145-150 °C5 mm Hg(lit.)
	Molecular Formula	C₆H₁₀O₃	Melting Point	28 °C(lit.)
	MSDS	USA	Flash Point	>230 °F

Use of DL-Mevalonolactone

DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (∆Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling[1][2].

Name	DL-Mevalonolactone
Synonym	More Synonyms

Description	DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (∆Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
References	[1]. Domingos SR, et al. On the structural intricacies of a metabolic precursor: Direct spectroscopic detection of water-induced conformational reshaping of mevalonolactone. J Chem Phys. 2017 Sep 28;147(12):124310. [2]. Cecatto C, et al. Mevalonolactone disrupts mitochondrial functions and induces permeability transition pore opening in rat brain mitochondria: Implications for the pathogenesis of mevalonic aciduria. Neurochem Int. 2017 Sep;108:133-145.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

References

[1]. Domingos SR, et al. On the structural intricacies of a metabolic precursor: Direct spectroscopic detection of water-induced conformational reshaping of mevalonolactone. J Chem Phys. 2017 Sep 28;147(12):124310.

[2]. Cecatto C, et al. Mevalonolactone disrupts mitochondrial functions and induces permeability transition pore opening in rat brain mitochondria: Implications for the pathogenesis of mevalonic aciduria. Neurochem Int. 2017 Sep;108:133-145.

Density	1.189 g/cm3
Boiling Point	145-150 °C5 mm Hg(lit.)
Melting Point	28 °C(lit.)
Molecular Formula	C₆H₁₀O₃
Molecular Weight	130.14200
Flash Point	>230 °F
Exact Mass	130.06300
PSA	46.53000
LogP	0.07440
Index of Refraction	n20/D 1.473(lit.)
Storage condition	2-8°C
Stability	Hygroscopic

DL-Mevalonolactone MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2932999099

Precursor 8
CAS#:7564-64-9 3-Methylpentane... CAS#:246237-03-6 5-[(4-nitrophen... CAS#:34695-32-4 4-Hydroxy-4-met... CAS#:114580-75-5 (R/S)-3-methyl-...
CAS#:246236-98-6 (4-nitrophenyl)... CAS#:246237-00-3 3-hydroxy-3-met... CAS#:99720-12-4 4-methyloxane-2... CAS#:2754-27-0 Trimethylsilyl ...
DownStream 8
CAS#:503-49-1 3-hydroxy-3-met... CAS#:19115-49-2 D-Mevalonolactone CAS#:7564-64-9 3-Methylpentane... CAS#:150-96-9 3-Hydroxy-3-met...
CAS#:19022-60-7 (4S)-4-hydroxy-... CAS#:2381-87-5 Dehydromevalono... CAS#:5788-94-3 Ergosta-2,24-di... CAS#:5119-48-2 Withaferin A

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

In vitro and in vivo anticancer effects of mevalonate pathway modulation on human cancer cells.

Br. J. Cancer 111(8) , 1562-71, (2014)

The increasing usage of statins (the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors) has revealed a number of unexpected beneficial effects, including a reduction in cancer risk.We investi...

Synthesis and HMG-CoA reductase inhibition of 2-cyclopropyl-4-thiophenyl-quinoline mevalonolactones.

Bioorg. Med. Chem. 17(23) , 7915-23, (2009)

A novel series of 2-cyclopropyl-4-thiophenyl quinoline-based mevalonolactones were synthesized from the substituted anilines by several reactions. Among them, (4R,6S)-6-[(E)-2-(2-cyclopropyl-6-fluoro-...

Highly sensitive assay of HMG-CoA reductase activity by LC-ESI-MS/MS.

J. Lipid Res. 48(5) , 1212-20, (2007)

We have developed a new sensitive and specific nonradioisotope assay method to measure the activity of HMG-CoA reductase, the rate-controlling enzyme in the cholesterol biosynthetic pathway. This meth...

(3RS)-mevalonolactone

MEVALONIC LACTONE

(+/-)-MEVALONOLACTONE

EINECS 211-615-0

DL-MEVALOLACTONE

MFCD00006648

DL-mevalonic acid lactone

D,L-MEVELONIC ACID LACTONE

MEVALONIC ACID LACTONE,DL

(RS)-mevalonolactone

(S/R)-mevalonolactone

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: DL-Mevalonolactone
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: DL-Mevalonolactone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: DL-Mevalonolactone
Price: ￥Inquiry/1kg ￥Inquiry/25kg ￥Inquiry/200kg
Purity: 99.0%
Delivery: 3 Day
Contact: Wang Jie
Email: 3096638339@qq.com

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