Vanoxerine dihydrochloride

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Names

[ CAS No. ]:
67469-78-7

[ Name ]:
Vanoxerine dihydrochloride

[Synonym ]:
1-{2-[Bis(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine dihydrochloride
Vanoxerine dihydrochloride
Piperazine, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)-, hydrochloride (1:2)
MFCD00055193
1-[2-[bis(4-fluorophenyl)methoxy]-ethyl]-4-[3-phenylpropyl]piperazine dihydrochloride
1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine,dihydrochloride
Vanoxerine hydrochloride
Vanoxerine (dihydrochloride)

Chemical & Physical Properties

[ Boiling Point ]:
542.7ºC at 760 mmHg

[ Melting Point ]:
221 °C

[ Molecular Formula ]:
C28H34Cl2F2N2O

[ Molecular Weight ]:
523.485

[ Flash Point ]:
282ºC

[ Exact Mass ]:
522.201599

[ PSA ]:
15.71000

[ LogP ]:
6.80100

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1-Bromo-3-phenylpropane
  • 1-[2-[bis(4-fluorophenyl)methoxy]-ethyl]piperazine
  • Vanoxerine
  • 1-(3-PENTYL)-PIPERAZINE
  • 4,4'-Diflurobenzylmethanol
  • 1-[2-chloroethoxy-(4-fluorophenyl)methyl]-4-fluorobenzene

DownStream

Articles

Serotonin at the level of the amygdala and orbitofrontal cortex modulates distinct aspects of positive emotion in primates.

Int. J. Neuropsychopharmacol. , 1-15, (2011)

Impaired top-down regulation of the amygdala, and its modulation by serotonin (5-HT), is strongly implicated in the dysregulation of negative emotion that characterizes a number of affective disorders...

Dopamine uptake inhibitors but not dopamine releasers induce greater increases in motor behavior and extracellular dopamine in adolescent rats than in adult male rats.

J. Pharmacol. Exp. Ther. 335(1) , 124-32, (2010)

Most life-long drug addiction begins during adolescence. Important structural and functional changes in brain occur during adolescence and developmental differences in forebrain dopamine systems could...

Differential effects of dopamine transporter inhibitors in the rodent Iowa gambling task: relevance to mania.

Psychopharmacology 225(3) , 661-74, (2013)

The Iowa Gambling Task (IGT) can be used to quantify impulsive and risky choice behaviors in psychiatric patients, e.g., bipolar disorder (BD) sufferers. Although developing treatments for these behav...


More Articles

Related Compounds

  • Vanoxerine dihydrochloride
  • Vanoxerine
  • Benzylhydrazine dihydrochloride
  • ethyl (2R)-2-[2-[[(2R)-1-ethoxy-1-oxo-3-sulfanylpropan-2-yl]amino]ethylamino]-3-sulfanylpropanoate,dihydrochloride
  • Amustaline dihydrochloride
  • Furosine dihydrochloride
  • (1R,4R)-4-((1S)-1-Cyanoethyl)-1,2,3,4-tetrahydronaphthalene-1-carbonitrile
  • (1S,4S)-4-(2-Cyanoethyl)-1,2,3,4-tetrahydronaphthalene-1-carbonitrile
  • (1R,4S)-4-(2-Cyanoethyl)-1,2,3,4-tetrahydronaphthalene-1-carbonitrile
  • 5-[(7Z)-Pentadec-7-en-1-yl]benzene-1,3-diol
  • 3-[(7Z)-Pentadec-7-en-1-yl]phenol
  • 3-(Pentadec-7-en-1-yl)phenol
  • 2-(4-Chlorophenyl)-3-cyclopropyl-1-(4H-1,2,4-triazol-4-yl)butan-2-ol
  • 8-Hydroxy-2-phenyl-4H-naphtho[1,2-b]pyran-4-one
  • 4'-Ethyl-4-methyl[1,1'-bi(cyclohexan)]-3-ene
  • 28-Nor-17alpha(H)-hopane
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