Vanoxerine dihydrochloride
Vanoxerine dihydrochloride structure
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Common Name | Vanoxerine dihydrochloride | ||
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| CAS Number | 67469-78-7 | Molecular Weight | 523.485 | |
| Density | N/A | Boiling Point | 542.7ºC at 760 mmHg | |
| Molecular Formula | C28H34Cl2F2N2O | Melting Point | 221 °C | |
| MSDS | USA | Flash Point | 282ºC | |
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Serotonin at the level of the amygdala and orbitofrontal cortex modulates distinct aspects of positive emotion in primates.
Int. J. Neuropsychopharmacol. , 1-15, (2011) Impaired top-down regulation of the amygdala, and its modulation by serotonin (5-HT), is strongly implicated in the dysregulation of negative emotion that characterizes a number of affective disorders. However, the contribution of these mechanisms to the regu... |
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Dopamine uptake inhibitors but not dopamine releasers induce greater increases in motor behavior and extracellular dopamine in adolescent rats than in adult male rats.
J. Pharmacol. Exp. Ther. 335(1) , 124-32, (2010) Most life-long drug addiction begins during adolescence. Important structural and functional changes in brain occur during adolescence and developmental differences in forebrain dopamine systems could mediate a biologic vulnerability to drug addiction during ... |
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Differential effects of dopamine transporter inhibitors in the rodent Iowa gambling task: relevance to mania.
Psychopharmacology 225(3) , 661-74, (2013) The Iowa Gambling Task (IGT) can be used to quantify impulsive and risky choice behaviors in psychiatric patients, e.g., bipolar disorder (BD) sufferers. Although developing treatments for these behaviors is important, few predictive animal models exist. Inhi... |
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Dopamine transporter-dependent and -independent striatal binding of the benztropine analog JHW 007, a cocaine antagonist with low abuse liability.
J. Pharmacol. Exp. Ther. 335(3) , 703-14, (2010) The benztropine analog N-(n-butyl)-3α-[bis(4'-fluorophenyl)methoxy]-tropane (JHW 007) displays high affinity for the dopamine transporter (DAT), but unlike typical DAT ligands, has relatively low abuse liability and blocks the effects of cocaine, including it... |
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Attention deficit/hyperactivity disorder-derived coding variation in the dopamine transporter disrupts microdomain targeting and trafficking regulation.
J. Neurosci. 32(16) , 5385-97, (2012) Attention deficit/hyperactivity disorder (ADHD) is the most commonly diagnosed disorder of school-age children. Although genetic and brain-imaging studies suggest a contribution of altered dopamine (DA) signaling in ADHD, evidence of signaling perturbations c... |
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Soluble interleukin-6 receptor induces motor stereotypies and co-localizes with gp130 in regions linked to cortico-striato-thalamo-cortical circuits.
PLoS ONE 7(7) , e41623, (2012) Soluble cytokine receptors are normal constituents of body fluids that regulate peripheral cytokine and lymphoid activity and whose levels are increased in states of immune activation. Soluble interleukin-6 receptor (sIL-6R) levels positively correlate with d... |
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Protective effect of aripiprazole against glutamate cytotoxicity in dopaminergic neurons of rat mesencephalic cultures.
Neurosci. Lett. 481(2) , 78-81, (2010) Aripiprazole, a dopamine D(2) receptor partial agonist, is used to treat schizophrenia. Although aripiprazole has been reported to protect non-dopaminergic neurons, its effect on dopaminergic neurons has yet to be investigated. In the present study, we examin... |
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Role of dopamine D1- and D2-like receptor mechanisms in drug-seeking following methamphetamine self-administration in rats.
Pharmacol. Biochem. Behav. 98(3) , 449-54, (2011) It has been suggested that dopaminergic mechanisms mediate relapse to drug-seeking behavior and both D1- and D2-like receptor mechanisms have been implicated. In contrast to self-administration of other drugs, there is a relative paucity of studies that has e... |
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Opposing effects of 5,7-DHT lesions to the core and shell of the nucleus accumbens on the processing of irrelevant stimuli.
Int. J. Neuropsychopharmacol. 15(4) , 485-96, (2012) There is good evidence that forebrain serotonergic systems modulate cognitive flexibility. Latent inhibition (LI) is a cross-species phenomenon which manifests as poor conditioning to a stimulus that has previously been experienced without consequence and is ... |
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Dopamine mediates cocaine-induced conditioned taste aversions as demonstrated with cross-drug preexposure to GBR 12909
Pharmacol. Biochem. Behav. 102(2) , 269-74, (2012) Although cocaine readily induces taste aversions, little is known about the mechanisms underlying this effect. It has been suggested that its inhibitory effects at one of the monoamine transporters may be mediating this suppression. Using the cross-drug preex... |